Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice

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2010-01-01
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Alvarenga, Tathiana Aparecida [UNIFESP]
Andersen, Monica Levy [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
Araujo, Paula [UNIFESP]
Hirotsu, Camila [UNIFESP]
Costa, José Luiz da
Battisti, Murilo Campos [UNIFESP]
Tufik, Sergio [UNIFESP]
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We evaluated the overall genetic damage induced by different doses of cocaine and MDMA (3,4-Methylenedioxymethamphetamine) in several organs. One hour after intraperitoneal drug administration, mice were euthanized; peripheral blood, liver and brain were collected, and the cellular suspensions were used for the single cell gel (comet) assay. We determined that all doses of cocaine and MDMA tested were able to induce DNA damage in blood cells. Extensive genotoxic damage was induced by cocaine or MDMA at the highest doses used in liver cells. Brain cells were affected by all doses administrated. These findings demonstrate that cocaine and MDMA are potent genotoxins.
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Addiction Biology. Malden: Wiley-Blackwell Publishing, Inc, v. 15, n. 1, p. 96-99, 2010.
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