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dc.contributor.authorSesso, Ricardo de Castro Cintra [UNIFESP]
dc.contributor.authorFranco, Maria do Carmo Pinho [UNIFESP]
dc.identifier.citationAmerican Journal of Hypertension. New York: Nature Publishing Group, v. 23, n. 1, p. 6-11, 2010.
dc.description.abstractBACKGROUNDAlthough numerous studies suggest an inverse relationship between birth weight and cardiovascular disease, the mechanistic basis of this phenomenon is not fully understood. Here, we postulate that alterations in plasma concentration of matrix metalloproteinases (MMPs) and growth factors might show different associations between birth weight, blood pressure levels, and vascular function.METHODSConcentrations of MMP-2 and its tissue inhibitor 2 (TIMP-2), MMP-9, and insulin-like growth factor-I (IGF-I) and its binding protein IGFBP-3 were measured in 64 children (34 boys, 30 girls).RESULTSSmall-for-gestational-age children exhibited elevated amounts of MMP-2, MMP-9, MMP-2/TIMP-2 ratio, MMP-9/TIMP-2 ratio, as well as lower concentration of IGF-I (P < 0.01), a known regulator of elastin synthesis. Similar findings were observed after adjustment for current age, gender, and race. the changes in the circulating levels of MMP-2, MMP-9, and IGF-I correlated significantly with birth weight, systolic blood pressure, and vascular function. Stepwise regression analysis demonstrated that MMP-2 was found to be an independent predictor of systolic blood pressure (R(2) = 0.08), whereas MMP-9 and birth weight were independent predictors of vascular dysfunction (R(2) = 0.38).CONCLUSIONSIt is possible that the association of fetal programming with elevated risk for vascular and metabolic disease in later life is, at least in part, mediated by perturbations in the MMP pathways.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.publisherNature Publishing Group
dc.relation.ispartofAmerican Journal of Hypertension
dc.rightsAcesso restrito
dc.subjectBirth weighten
dc.subjectBlood pressureen
dc.subjectEndothelium functionen
dc.subjectMatrix metalloproteinasesen
dc.titleAbnormalities in Metalloproteinase Pathways and IGF-I Axis: A Link Between Birth Weight, Hypertension, and Vascular Damage in Childhooden
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade Federal de São Paulo, Sch Med, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sch Med, Div Nephrol, São Paulo, Brazil
dc.description.sponsorshipIDCNPq: 470504/2007-2
dc.description.sponsorshipIDFAPESP: 04/10342-7
dc.description.sourceWeb of Science

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