Etiology of childhood diarrhea in the northeast of Brazil: significant emergent diarrheal pathogens
Ramos Moreno, Ana Carolina
Fernandes Filho, Antonio
Tardelli Gomes, Tania do Amaral [UNIFESP]
Ramos, Sonia T. S.
Montemor, Liana P. G.
Tavares, Vanessa C.
Santos Filho, Lauro dos
Martinez, Marina Baquerizo
Is part ofDiagnostic Microbiology and Infectious Disease
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In a study conducted in Joao Pessoa, northeast of Brazil, 2344 Escherichia coli isolated from 290 infants with diarrhea and 290 healthy matched controls were analyzed for virulence traits. Enteroaggregative E. coli (EAEC) was the most prevalent pathogen associated to acute diarrhea. Based on the results of colony blot hybridization, serotyping, and HEp-2 cell adherence assays, strains were separated in categories as typical enteropathogenic E. coli (EPEC) (1.7%), atypical EPEC (a-EPEC) (9.3%), EAEC (25%), enterotoxigenic E. coli (10%), and enteroinvasive E. coli (EIEC) (1.4%). No enterohemorrhagic E. coli strains were isolated. Other enteropathogens were found, including Salmonella (7.9%), Shigella spp. (4.1%), thermophilic Campylobacter spp. (2.4%), Giardia lamblia (9.3%), and Entamoeba histolytica (5.8%). All enteropathogens were associated with diarrhea (P < 0.01). However, the association was lower for EPEC and EIEC (P < 0.03). Different pathogens associated with diarrhea may have been changing in Brazil where EAEC and a-EPEC seem to be the most prevalent pathogens among them. (C) 2010 Elsevier Inc. All rights reserved.
CitationDiagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 66, n. 1, p. 50-57, 2010.
SponsorshipArlinda Marques Pediatric Hospital
Center for Tropical Medicine at the Federal University of Paraiba, Paraiba, Brazil
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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