Effects of soy isoflavones on the uterus and urethra of ovariectomized rats
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2010-01-01
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Santos, Elaine Travaglia [UNIFESP]
Dutra Sampaio, Maria Dione [UNIFESP]
Cecon, Paulo Roberto
Simoes, Manuel de Jesus [UNIFESP]
Ferreira Sartori, Marair Gracio [UNIFESP]
Batista Castello Girao, Manoel Joao [UNIFESP]
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To evaluate the effect of soy isoflavone extract (SIE) on the uterus and urethra of castrated female rats.Ovariectomized adult virgin Wistar rats (n = 45) received, for 30 days: placebo (GI); SIE from day 5 of castration (GII); or day 28 of castration (GIII). A standardized SIE was administered by gavage at 125 mu g genistein/g body weight/day, with a soy-free diet. Average numbers of nuclei (NU), blood vessels (BV) and collagen fibers (CF) in uterus and mid-urethra sections were compared using Dunnett and Tukey tests (95% CI).Uterus: GII and GIII differed from GI in all respects; GII vs. GIII, no differences. Urethra: GIII vs. GI: no differences; GII vs. GI, differences in NU and CF; GII vs. GIII, differences in NU and CF.Early oral administration of SIE to ovariectomized rats reversed uterine/urethral effects of castration.
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International Urogynecology Journal. Artington: Springer London Ltd, v. 21, n. 1, p. 111-116, 2010.