Effects of soy isoflavones on the uterus and urethra of ovariectomized rats

Effects of soy isoflavones on the uterus and urethra of ovariectomized rats

Author Santos, Elaine Travaglia Autor UNIFESP Google Scholar
Dutra Sampaio, Maria Dione Autor UNIFESP Google Scholar
Cecon, Paulo Roberto Google Scholar
Simoes, Manuel de Jesus Autor UNIFESP Google Scholar
Ferreira Sartori, Marair Gracio Autor UNIFESP Google Scholar
Batista Castello Girao, Manoel Joao Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Viçosa (UFV)
Abstract To evaluate the effect of soy isoflavone extract (SIE) on the uterus and urethra of castrated female rats.Ovariectomized adult virgin Wistar rats (n = 45) received, for 30 days: placebo (GI); SIE from day 5 of castration (GII); or day 28 of castration (GIII). A standardized SIE was administered by gavage at 125 mu g genistein/g body weight/day, with a soy-free diet. Average numbers of nuclei (NU), blood vessels (BV) and collagen fibers (CF) in uterus and mid-urethra sections were compared using Dunnett and Tukey tests (95% CI).Uterus: GII and GIII differed from GI in all respects; GII vs. GIII, no differences. Urethra: GIII vs. GI: no differences; GII vs. GI, differences in NU and CF; GII vs. GIII, differences in NU and CF.Early oral administration of SIE to ovariectomized rats reversed uterine/urethral effects of castration.
Keywords Isoflavones
Urethra
Uterus
Menopause
Rat
Soy
Language English
Date 2010-01-01
Published in International Urogynecology Journal. Artington: Springer London Ltd, v. 21, n. 1, p. 111-116, 2010.
ISSN 0937-3462 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 111-116
Origin http://dx.doi.org/10.1007/s00192-009-0995-6
Access rights Closed access
Type Article
Web of Science ID WOS:000272463500015
URI http://repositorio.unifesp.br/handle/11600/32075

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