Thrombin Inhibitors from Different Animals

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Data
2010-01-01
Autores
Tanaka-Azevedo, A. M.
Morais-Zani, K.
Torquato, R. J. S. [UNIFESP]
Tanaka, A. S. [UNIFESP]
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Resumo
Venous and arterial thromboembolic diseases are still the most frequent causes of death and disability in high-income countries. Clinical anticoagulants are inhibitors of enzymes involved in the coagulation pathway, such as thrombin and factor Xa. Thrombin is a key enzyme of blood coagulation system, activating the platelets, converting the fibrinogen to the fibrin net, and amplifying its self-generation by the activation of factors V, VIII, and XI. Thrombin has long been a target for the development of oral anticoagulants. Furthermore, selective inhibitors of thrombin represent a new class of antithrombotic agents. for these reasons, a number of specific thrombin inhibitors are under evaluation for possible use as antithrombotic drugs. This paper summarizes old and new interests of specific thrombin inhibitors described in different animals.
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Journal of Biomedicine and Biotechnology. New York: Hindawi Publishing Corporation, 9 p., 2010.
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