Carbamazepine damage to rat spermatogenesis in different sexual developmental phases

Carbamazepine damage to rat spermatogenesis in different sexual developmental phases

Author Oliva, Samara Urban de Autor UNIFESP Google Scholar
Miraglia, Sandra Maria Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract P>Carbamazepine (CBZ) is a first-line antiepileptic drug (AED), although it is also utilized for treatment of psychiatric disorders and neuropathic pain. the utilization of CBZ has been associated with damage to male reproduction including hormonal alterations, sexual dysfunction and reduction of sperm quality. Wide and long-term use of CBZ has been a common schedule for children and adolescents, despite the fact it alters the testosterone level in adult rats and humans. in addition, hypothalamic-pituitary-gonadal (HPG) axis during pre-puberty and puberty is more susceptible to toxic agents than in adult phase. the objective of this work was to evaluate the side effects of CBZ on the spermatogenic process of rats from pre-puberty to puberty and sexual maturation. Damage on the seminiferous epithelium, testicular interstitial oedema, reductions of testosterone levels and an increase in oestradiol levels were observed in rats, which were CBZ-treated since the weaning. the results suggest that CBZ, when administered from pre-puberty, provokes specific side effects on rat testes, resulting in more severe damage in the adult phase.
Keywords carbamazepine
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2009-10-01
Published in International Journal of Andrology. Malden: Wiley-Blackwell Publishing, Inc, v. 32, n. 5, p. 563-574, 2009.
ISSN 0105-6263 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 563-574
Access rights Closed access
Type Article
Web of Science ID WOS:000269591000016

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