Voxel-based morphometry evaluation of patients with photosensitive juvenile myoclonic epilepsy

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2009-10-01
Autores
Lin, Katia [UNIFESP]
Jackowski, Andrea Parolin [UNIFESP]
Carrete Junior, Henrique [UNIFESP]
Araujo Filho, Gerardo Maria de [UNIFESP]
Silva, Henrique Hattori [UNIFESP]
Bittar Guaranha, Mirian Salvadori [UNIFESP]
Figueiredo Ferreira Guilhoto, Laura Maria [UNIFESP]
Bressan, Rodrigo Affonseca [UNIFESP]
Targas Yacubian, Elza Marcia [UNIFESP]
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We aim to investigate structural brain abnormalities in juvenile myoclonic epilepsy (JME) patients with photosensitivity (PS). Sixty JME patients, 19 (32%) of whom were photosensitive, were submitted to 1.5 T magnetic resonance voxel-based morphometry (VBM). the control group (CTL) consisted of 30 sex-matched healthy volunteers. JME patients with (JME-PS) and without (JME-NPS) PS did not differ in their duration of disease, treatment or seizure control. VBM revealed significantly reduced bilateral gray matter volume (GMV) in thalami, insula cortices and cerebellar hemispheres; while significantly increased GMV was observed in the right superior frontal, orbitofrontal and medial. frontal gyri of the JME group compared to CTL. JME-PS had reduced bilateral GMV of visual cortices when compared with CTL; white it was not seen among JME-NPS patients. Reduced left hippocampus and left inferior frontal gyrus volume was observed among JME-PS compared with JME-NPS. This study demonstrates structural abnormalities beyond the limits of the frontal lobes and provides evidence for the role of the occipital cortex in human PS, reinforcing the existence of functional-anatomic ictogenic networks in JME and the concept of 'system epitepsies'. (C) 2009 Elsevier B.V. All rights reserved.
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Epilepsy Research. Amsterdam: Elsevier B.V., v. 86, n. 2-3, p. 138-145, 2009.