Homocysteine and cysteine concentrations are modified by recent exposure to environmental air pollution in São Paulo, Brazil

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dc.contributor.author Abe, Karina Camasmie [UNIFESP]
dc.contributor.author Brandao, Leticia de Campos [UNIFESP]
dc.contributor.author Aguilar Calegare, Bruno Frederico [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Nascimento Saldiva, Paulo Hilario do
dc.contributor.author D'Almeida, Vania [UNIFESP]
dc.date.accessioned 2016-01-24T13:58:47Z
dc.date.available 2016-01-24T13:58:47Z
dc.date.issued 2009-10-01
dc.identifier http://dx.doi.org/10.1016/j.envres.2009.06.007
dc.identifier.citation Environmental Research. San Diego: Academic Press Inc Elsevier Science, v. 109, n. 7, p. 887-890, 2009.
dc.identifier.issn 0013-9351
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/31858
dc.description.abstract Millions of people worldwide are affected by anthropogenic air pollution derived from the combustion of fossil fuels. in this work, we tested the effects of fetal, lactation and post-weaning ambient air pollution exposure on total homocysteine (tHcy) concentrations and on a downstream pathway element, the plasma cysteine (Cys) concentration. Two similar exposure chambers (polluted and filtered chamber) were located near an area with heavy traffic in São Paulo, Brazil, and male Swiss mice were housed there from the pre-natal period until 3 months of age. Groups during fetal, lactation and adult periods of exposure were apportioned, and tHcy and Cys plasma concentrations were assessed when the animals were 3 months old. in our study, both the tHcy and Cys concentrations were decreased in groups that spent their final stage of life in polluted chambers, suggesting recent alterations in tHcy and Cys concentrations due to air pollution exposure. the possible relationship of these data with cardiovascular dysfunction is still a matter of controversy in animals; nevertheless, epigenetic mechanisms emerge as a possible issue to consider in the investigation of the link between air pollution and Hcy measurement. (C) 2009 Elsevier Inc. All rights reserved. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship AFIP
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Department of Psychobiology of UNIFESP
dc.format.extent 887-890
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Environmental Research
dc.rights Acesso restrito
dc.subject Air pollution en
dc.subject Homocysteine en
dc.subject Cysteine en
dc.subject Traffic en
dc.subject Mouse en
dc.title Homocysteine and cysteine concentrations are modified by recent exposure to environmental air pollution in São Paulo, Brazil en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Biosci, BR-04024002 São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Dept Pathol, Lab Air Pollut, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biosci, BR-04024002 São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2007/07624-9
dc.description.sponsorshipID CNPq: 501248/2005-6
dc.identifier.doi 10.1016/j.envres.2009.06.007
dc.description.source Web of Science
dc.identifier.wos WOS:000270252600013



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