Homocysteine and cysteine concentrations are modified by recent exposure to environmental air pollution in São Paulo, Brazil

Homocysteine and cysteine concentrations are modified by recent exposure to environmental air pollution in São Paulo, Brazil

Author Abe, Karina Camasmie Autor UNIFESP Google Scholar
Brandao, Leticia de Campos Autor UNIFESP Google Scholar
Aguilar Calegare, Bruno Frederico Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Nascimento Saldiva, Paulo Hilario do Google Scholar
D'Almeida, Vania Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Millions of people worldwide are affected by anthropogenic air pollution derived from the combustion of fossil fuels. in this work, we tested the effects of fetal, lactation and post-weaning ambient air pollution exposure on total homocysteine (tHcy) concentrations and on a downstream pathway element, the plasma cysteine (Cys) concentration. Two similar exposure chambers (polluted and filtered chamber) were located near an area with heavy traffic in São Paulo, Brazil, and male Swiss mice were housed there from the pre-natal period until 3 months of age. Groups during fetal, lactation and adult periods of exposure were apportioned, and tHcy and Cys plasma concentrations were assessed when the animals were 3 months old. in our study, both the tHcy and Cys concentrations were decreased in groups that spent their final stage of life in polluted chambers, suggesting recent alterations in tHcy and Cys concentrations due to air pollution exposure. the possible relationship of these data with cardiovascular dysfunction is still a matter of controversy in animals; nevertheless, epigenetic mechanisms emerge as a possible issue to consider in the investigation of the link between air pollution and Hcy measurement. (C) 2009 Elsevier Inc. All rights reserved.
Keywords Air pollution
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Department of Psychobiology of UNIFESP
Grant number FAPESP: 2007/07624-9
CNPq: 501248/2005-6
Date 2009-10-01
Published in Environmental Research. San Diego: Academic Press Inc Elsevier Science, v. 109, n. 7, p. 887-890, 2009.
ISSN 0013-9351 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 887-890
Origin http://dx.doi.org/10.1016/j.envres.2009.06.007
Access rights Closed access
Type Article
Web of Science ID WOS:000270252600013
URI http://repositorio.unifesp.br/handle/11600/31858

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