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dc.contributor.authorMoraes, Andrea B. [UNIFESP]
dc.contributor.authorHaidar, Mauro Abi [UNIFESP]
dc.contributor.authorSoares Junior, Jose Maria [UNIFESP]
dc.contributor.authorSimoes, Manuel J. [UNIFESP]
dc.contributor.authorBaracat, Edmund C.
dc.contributor.authorPatriarca, Marisa T. [UNIFESP]
dc.date.accessioned2016-01-24T13:58:47Z
dc.date.available2016-01-24T13:58:47Z
dc.date.issued2009-10-01
dc.identifierhttp://dx.doi.org/10.1016/j.ejogrb.2009.04.007
dc.identifier.citationEuropean Journal of Obstetrics & Gynecology and Reproductive Biology. Clare: Elsevier B.V., v. 146, n. 2, p. 188-192, 2009.
dc.identifier.issn0301-2115
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31856
dc.description.abstractObjective: the aim of this study was to evaluate the effects of estrogen and isoflavones on postmenopausal skin morphological parameters.Study design: A randomized, double-blind, estrogen-controlled trial was performed on postmenopausal women treated in the Gynecology Department of the Federal University of São Paulo. This study was designed to analyze the effects of topical administration of estradiol and isoflavones on facial skin for 24 weeks. the participants were divided into two groups: G1-17-betaestradiol 0.01% (n = 18) and G2-isoflavones 40% (genistein 4%, n = 18). Skin biopsies were performed on each patient before and after the treatment. the skin samples were processed for histological analysis, stained with haematoxylin and eosin, and examined using light microscopy.Results: After 24 weeks of treatment, the estradiol group had a significant increase in skin parameters analyzed compared to the isoflavone group and to the baseline measurements: epidermal thickness (a 75% increase in the estrogen group and 20% in the isoflavone group), number of dermal papillae (a rise of 125% with estrogen, no significant gain with isoflavones), fibroblasts (a 123% accretion with estradiol, no significant gain with isoflavones), and vessels (a 77% increase with estrogen and 36% with isoflavones).Conclusion: Our data suggest that estrogens may have a stronger effect on histomorphometrical parameters than isoflavones. (C) 2009 Elsevier Ireland Ltd. All rights reserved.en
dc.format.extent188-192
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
dc.rightsAcesso restrito
dc.subjectEstrogenen
dc.subjectIsoflavonesen
dc.subjectSkinen
dc.subjectPostmenopauseen
dc.titleThe effects of topical isoflavones on postmenopausal skin: Double-blind and randomized clinical trial of efficacyen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniversidade Federal de São Paulo, Dept Gynecol, Div Endocrinol Gynecol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Dept Obstet & Ginecol, BR-05508 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Gynecol, Div Endocrinol Gynecol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morphol, São Paulo, Brazil
dc.identifier.doi10.1016/j.ejogrb.2009.04.007
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000271360500015


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