The effects of topical isoflavones on postmenopausal skin: Double-blind and randomized clinical trial of efficacy

The effects of topical isoflavones on postmenopausal skin: Double-blind and randomized clinical trial of efficacy

Author Moraes, Andrea B. Autor UNIFESP Google Scholar
Haidar, Mauro Abi Autor UNIFESP Google Scholar
Soares Junior, Jose Maria Autor UNIFESP Google Scholar
Simoes, Manuel J. Autor UNIFESP Google Scholar
Baracat, Edmund C. Google Scholar
Patriarca, Marisa T. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Objective: the aim of this study was to evaluate the effects of estrogen and isoflavones on postmenopausal skin morphological parameters.Study design: A randomized, double-blind, estrogen-controlled trial was performed on postmenopausal women treated in the Gynecology Department of the Federal University of São Paulo. This study was designed to analyze the effects of topical administration of estradiol and isoflavones on facial skin for 24 weeks. the participants were divided into two groups: G1-17-betaestradiol 0.01% (n = 18) and G2-isoflavones 40% (genistein 4%, n = 18). Skin biopsies were performed on each patient before and after the treatment. the skin samples were processed for histological analysis, stained with haematoxylin and eosin, and examined using light microscopy.Results: After 24 weeks of treatment, the estradiol group had a significant increase in skin parameters analyzed compared to the isoflavone group and to the baseline measurements: epidermal thickness (a 75% increase in the estrogen group and 20% in the isoflavone group), number of dermal papillae (a rise of 125% with estrogen, no significant gain with isoflavones), fibroblasts (a 123% accretion with estradiol, no significant gain with isoflavones), and vessels (a 77% increase with estrogen and 36% with isoflavones).Conclusion: Our data suggest that estrogens may have a stronger effect on histomorphometrical parameters than isoflavones. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
Keywords Estrogen
Language English
Date 2009-10-01
Published in European Journal of Obstetrics & Gynecology and Reproductive Biology. Clare: Elsevier B.V., v. 146, n. 2, p. 188-192, 2009.
ISSN 0301-2115 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 188-192
Access rights Closed access
Type Article
Web of Science ID WOS:000271360500015

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