Antimicrobial susceptibility of Gram-positive bacteria isolated from US medical centers: results of the Daptomycin Surveillance Program (2007-2008)

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dc.contributor.author Sader, Helio S. [UNIFESP]
dc.contributor.author Jones, Ronald N.
dc.date.accessioned 2016-01-24T13:58:47Z
dc.date.available 2016-01-24T13:58:47Z
dc.date.issued 2009-10-01
dc.identifier http://dx.doi.org/10.1016/j.diagmicrobio.2009.06.016
dc.identifier.citation Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 65, n. 2, p. 158-162, 2009.
dc.identifier.issn 0732-8893
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/31855
dc.description.abstract Gram-positive bacterial strains (12 443) consecutively collected during 2007 to 2008 in hospitals located in the United States were tested by reference broth microdilution methods against daptomycin and comparison agents. Methicillin (oxacillin) resistance rates were 55.9% and 74.0% for Staphylococcus aureus and coagulase-negative staphylococci, respectively, and the vancomycin resistance rate among Enterococcus faecalis and Enterococcus faecium were 5.4% and 75.4%, respectively. Daptomycin was very active against all Gram-positive species with MIC90 values of 0.5, 0.25, 0.5, and 2 mu g/mL for staphylococci, beta-hemolytic streptococci, viridans group streptococci, and enterococci, respectively. Overall, 99.9% of S. aureus, 100.0% of E. faecalis, and 99.5% of E.faecium were susceptible to daptomycin. in addition, daptomycin MIC distributions for S. aureus and enterococci from 2007 to 2008 were very similar to those from 2002 to 2003. in summary, high rates of methicillin-resistant staphylococci and vancomycin-resistant enterococci were observed in US hospitals, but daptomycin remains active against these clinically important Gram-positive organisms with no evidence of potency loss since its approval for clinical use in late 2003. (C) 2009 Published by Elsevier Inc. en
dc.format.extent 158-162
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Diagnostic Microbiology and Infectious Disease
dc.rights Acesso restrito
dc.subject Daptomycin en
dc.subject Gram-positive pathogens en
dc.subject Resistance en
dc.subject Surveillance en
dc.title Antimicrobial susceptibility of Gram-positive bacteria isolated from US medical centers: results of the Daptomycin Surveillance Program (2007-2008) en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution JMI Labs
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Tufts Univ
dc.description.affiliation JMI Labs, N Liberty, IA 52317 USA
dc.description.affiliation Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliation Tufts Univ, Sch Med, Boston, MA 02111 USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo, São Paulo, Brazil
dc.identifier.doi 10.1016/j.diagmicrobio.2009.06.016
dc.description.source Web of Science
dc.identifier.wos WOS:000270260400012



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