Antimicrobial susceptibility of Gram-positive bacteria isolated from US medical centers: results of the Daptomycin Surveillance Program (2007-2008)

Antimicrobial susceptibility of Gram-positive bacteria isolated from US medical centers: results of the Daptomycin Surveillance Program (2007-2008)

Author Sader, Helio S. Autor UNIFESP Google Scholar
Jones, Ronald N. Google Scholar
Institution JMI Labs
Universidade Federal de São Paulo (UNIFESP)
Tufts Univ
Abstract Gram-positive bacterial strains (12 443) consecutively collected during 2007 to 2008 in hospitals located in the United States were tested by reference broth microdilution methods against daptomycin and comparison agents. Methicillin (oxacillin) resistance rates were 55.9% and 74.0% for Staphylococcus aureus and coagulase-negative staphylococci, respectively, and the vancomycin resistance rate among Enterococcus faecalis and Enterococcus faecium were 5.4% and 75.4%, respectively. Daptomycin was very active against all Gram-positive species with MIC90 values of 0.5, 0.25, 0.5, and 2 mu g/mL for staphylococci, beta-hemolytic streptococci, viridans group streptococci, and enterococci, respectively. Overall, 99.9% of S. aureus, 100.0% of E. faecalis, and 99.5% of E.faecium were susceptible to daptomycin. in addition, daptomycin MIC distributions for S. aureus and enterococci from 2007 to 2008 were very similar to those from 2002 to 2003. in summary, high rates of methicillin-resistant staphylococci and vancomycin-resistant enterococci were observed in US hospitals, but daptomycin remains active against these clinically important Gram-positive organisms with no evidence of potency loss since its approval for clinical use in late 2003. (C) 2009 Published by Elsevier Inc.
Keywords Daptomycin
Gram-positive pathogens
Resistance
Surveillance
Language English
Date 2009-10-01
Published in Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 65, n. 2, p. 158-162, 2009.
ISSN 0732-8893 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 158-162
Origin http://dx.doi.org/10.1016/j.diagmicrobio.2009.06.016
Access rights Closed access
Type Article
Web of Science ID WOS:000270260400012
URI http://repositorio.unifesp.br/handle/11600/31855

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