Underlying mechanism of portal hypertensive gastropathy in cirrhosis: A hemodynamic and morphological approach

Underlying mechanism of portal hypertensive gastropathy in cirrhosis: A hemodynamic and morphological approach

Author Curvelo, Lilian Amorim Autor UNIFESP Google Scholar
Brabosa, Walnei Autor UNIFESP Google Scholar
Rhor, Rachel Autor UNIFESP Google Scholar
Lanzoni, Valeria Autor UNIFESP Google Scholar
Parise, Edison Roberto Autor UNIFESP Google Scholar
Ferrari, Angelo Paulo Autor UNIFESP Google Scholar
Kondo, Mario Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background and Aim:Portal hypertensive gastropathy (PHG) is an important cause of bleeding in patients with cirrhosis associated with portal hypertension. Histologically, the condition is characterized by dilation of the mucosal and submucosal vessels of the stomach; however, its mechanisms remain unclear. the aim of the present cross-sectional study was to evaluate the role of portal and systemic hemodynamic features, humoral factors and hepatocellular function in the development and severity of PHG in patients with cirrhosis.Methods:Forty-six patients with cirrhosis of different etiologies underwent endoscopy. Portal hypertension was evaluated by hepatic venous pressure gradient (HVPG). the gastric mucosa was analyzed using two diagnostic methods: endoscopy according to the McCormack criteria and histological by histomorphometric analysis.Results:The prevalence of PHG according to the endoscopic and histomorphometric methods was 93.4% and 76.1%, respectively. There were no statistically significant differences in HVPG measurements between the patients with mild (16.0 +/- 5.9 mmHg) and severe PHG (16.9 +/- 6.5 mmHg; P = 0.80) or between patients who did not have (15.2 +/- 8.0 mmHg) and those who had PHG (16.3 +/- 5.7 mmHg). No correlation was found between the presence or severity of PHG and systemic vascular resistance index (P = 0.53 and 0.34, respectively), Child-Pugh classification (P = 0.73 and 0.78, respectively) or glucagon levels (P = 0.59 and 0.62, respectively).Conclusions:The present data show no correlation between the presence or the severity of PHG and portal pressure, Child-Pugh classification or systemic hemodynamics, suggesting that other factors may be involved in the physiopathology of PHG, such as local gastric mucosal factors or other underlying factors.
Keywords cirrhosis
hepatocellular function
portal hemodynamics
portal hypertension
portal hypertensive gastropathy
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2009-09-01
Published in Journal of Gastroenterology and Hepatology. Malden: Wiley-Blackwell Publishing, Inc, v. 24, n. 9, p. 1541-1546, 2009.
ISSN 0815-9319 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1541-1546
Origin http://dx.doi.org/10.1111/j.1440-1746.2009.05871.x
Access rights Closed access
Type Article
Web of Science ID WOS:000269582900013
URI http://repositorio.unifesp.br/handle/11600/31802

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