An MRI-based approach for the measurement of the dorsolateral prefrontal cortex in humans

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Sanches, Marsal [UNIFESP]
Caetano, Sheila
Nicoletti, Mark
Monkul, E. Serap
Chen, Hua Hsuan
Hatch, John P.
Yeh, Ping-Hong
Mullis, Rachel L.
Keshavan, Matcheri S.
Rajowska, Grazyna
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The dorsolateral prefrontal cortex (DLPFC) has been implicated in the pathophysiology of mental disorders. Previous region-of-interest MRI studies that attempted to delineate this region adopted various landmarks and measurement techniques, with inconsistent results. We developed a new region-of-interest measurement method to obtain morphometric data of this region from structural MRI scans, taking into account knowledge from cytoarchitectonic postmortem studies and the large inter-individual variability of this region. MRI scans of 10 subjects were obtained, and DLPFC tracing was performed in the coronal plane by two independent raters using the semi-automated software Brains2. the intra-class correlation coefficients between two independent raters were 0.94 for the left DLPFC and 0.93 for the right DLPFC. the mean +/- S.D. DLPFC volumes were 9.23 +/- 2.35 ml for the left hemisphere and 8.20 +/- 2.08 ml for the right hemisphere. Our proposed method has high inter-rater reliability and is easy to implement, permitting the standardized measurement of this region for clinical research applications. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
Psychiatry Research-neuroimaging. Clare: Elsevier B.V., v. 173, n. 2, p. 150-154, 2009.