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dc.contributor.authorAraujo Filho, Gerardo Maria de [UNIFESP]
dc.contributor.authorLin, Katia [UNIFESP]
dc.contributor.authorLin, Jaime [UNIFESP]
dc.contributor.authorPeruchi, Mirella M. [UNIFESP]
dc.contributor.authorCaboclo, Luis Otavio S. F. [UNIFESP]
dc.contributor.authorGuaranha, Mirian S. B. [UNIFESP]
dc.contributor.authorGuilhoto, Laura M. F. F. [UNIFESP]
dc.contributor.authorCarrete Junior, Henrique [UNIFESP]
dc.contributor.authorYacubian, Elza Márcia Targas [UNIFESP]
dc.identifier.citationEpilepsia. Malden: Wiley-Blackwell Publishing, Inc, v. 50, n. 5, p. 1201-1209, 2009.
dc.description.abstractPersonality traits characterized by emotional instability and immaturity, unsteadiness, lack of discipline, hedonism, frequent and rapid mood changes, and indifference toward one's disease have been associated with patients who have juvenile myoclonic epilepsy (JME). Literature data demonstrate worse seizure control and more psychosocial dysfunctions among patients with JME who have those traits. in this controlled study we performed a correlation analysis of psychiatric scores with magnetic resonance spectroscopy (MRS) values across JME patients, aiming to verify the existence of a possible relation between frontal lobe dysfunction and the prevalence of personality disorders (PDs) in JME.Sixteen JME patients with cluster B PDs, 41 JME patients without any psychiatric disorder, and 30 healthy controls were submitted to a psychiatric evaluation and to a quantitative multivoxel MRS of thalamus; insula; cingulate gyrus; striatum; and frontal, parietal, and occipital lobes. Groups were homogeneous according to age, gender, and manual dominance. Psychiatric evaluation was performed through the Scheduled Clinical Interview for DSM-IV, Axis I and II (SCID I and II, respectively).A significant reduction of N-acetyl-aspartate over creatinine (NAA/Cr) ratio was observed mainly in the left frontal lobe in the JME and PD group. in addition, a significant increase in the glutamate-glutamine over creatinine GLX/Cr ratio was also observed in this referred region in the same group.These data support the hypothesis that PDs in JME could represent neuronal dysfunction and possibly a more severe form of this epileptic syndrome.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.rightsAcesso aberto
dc.subjectMagnetic resonance spectroscopyen
dc.subjectIdiopathic generalized epilepsyen
dc.subjectJuvenile myoclonic epilepsyen
dc.subjectPersonality disordersen
dc.subjectFrontal lobe dysfunctionen
dc.subjectPsychiatric disordersen
dc.titleAre personality traits of juvenile myoclonic epilepsy related to frontal lobe dysfunctions? A proton MRS studyen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Diagnost Imaging, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Diagnost Imaging, São Paulo, Brazil
dc.description.sourceWeb of Science

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