Predictors of Recurrence of Ovarian Granulosa Cell Tumors

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dc.contributor.author Nosov, Vladimir
dc.contributor.author Silva, Ivaldo [UNIFESP]
dc.contributor.author Tavassoli, Fattaneh
dc.contributor.author Adamyan, Leiva
dc.contributor.author Farias-Eisner, Robin
dc.contributor.author Schwartz, Peter E.
dc.date.accessioned 2016-01-24T13:52:28Z
dc.date.available 2016-01-24T13:52:28Z
dc.date.issued 2009-05-01
dc.identifier http://journals.lww.com/ijgc/Fulltext/2009/05000/Predictors_of_Recurrence_of_Ovarian_Granulosa_Cell.23.aspx
dc.identifier.citation International Journal of Gynecological Cancer. Philadelphia: Lippincott Williams & Wilkins, v. 19, n. 4, p. 628-633, 2009.
dc.identifier.issn 1048-891X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/31474
dc.description.abstract Objective: the prognosis of granulosa cell tumors (GCTs) is overall favorable, but a proportion of patients will experience recurrence. We report one of the largest series of patients with GCT for whom clinical, morphologic, and immunohistochemical markers have been assessed for their roles as predictors of recurrence.Methods: Patients with the diagnosis of GCT were identified at 2 hospitals from 1974 to 2004; a detailed chart analysis was performed. Tissue blocks were analyzed immunohistochemically for mitotic index, luteinization, inhibin staining, epidermal growth factor receptor, and Ki67 expression. Univariate and multivariate analyses were performed.Results: Sixty-seven patients were identified. Follow-up data up to 30 years were available. the mean age at diagnosis was 48.1 years. Twenty-five patients experienced recurrence. A statistically significant correlation (P < 0.05) was observed for age at diagnosis, with earlier age being an adverse factor (43.6 vs 50.9, P < 0.01), and use of adjuvant chemotherapy postoperatively (24% vs 40% in the nonrecurrence group). Luteinization and the immunohistochemical markers, such as inhibin, Ki67, and epidermal growth factor receptor, seemed to significantly increase the risk of recurrence if expressed. A multivariate analysis model confirmed that younger age at diagnosis and higher expression of inhibin and Ki67 are significant risk factors of GCT recurrence.Conclusions: Identification of patients who are at a high risk for recurrence of GCT is critical. Routine treatment for all patients with cytotoxic chemotherapy is not justified. We report a set of predictors of recurrence for GCT that identified subsets of patients who may benefit from prolonged surveillance and/or adjuvant systemic chemotherapy. en
dc.format.extent 628-633
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof International Journal of Gynecological Cancer
dc.rights Acesso aberto
dc.subject Granulosa cell en
dc.subject Tumor en
dc.subject Recurrence en
dc.subject Marker en
dc.title Predictors of Recurrence of Ovarian Granulosa Cell Tumors en
dc.type Artigo
dc.contributor.institution Univ Calif Los Angeles
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Yale New Haven Med Ctr
dc.contributor.institution Kulakov Sci Ctr Obstet Gynecol & Perinatol
dc.description.affiliation Univ Calif Los Angeles, David Geffen Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90046 USA
dc.description.affiliation Universidade Federal de São Paulo, Dept Gynecol, São Paulo, Brazil
dc.description.affiliation Yale New Haven Med Ctr, Dept Pathol, New Haven, CT USA
dc.description.affiliation Kulakov Sci Ctr Obstet Gynecol & Perinatol, Dept Operat Gynecol, Moscow, Russia
dc.description.affiliation Yale New Haven Med Ctr, Dept Obstet Gynecol & Reprod Sci, New Haven, CT USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Gynecol, São Paulo, Brazil
dc.identifier.doi 10.1111/IGC.0b013e31381a48a6f
dc.description.source Web of Science
dc.identifier.wos WOS:000266976800022



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