L-Arginine Supplementation Protects Against Hepatic Ischemia-Reperfusion Lesions in Rabbits

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Taha, M. O. [UNIFESP]
Simoes, M. J. [UNIFESP]
Haddad, M. A. [UNIFESP]
Capelato, R. C.
Budny, N.
Matsumoto, A. H.
Soares, P. C. M.
Santos, W. M.
Armeato, G. D.
Araki, C. M.
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We evaluated the effects of a substrate in the biosynthesis of nitric oxide (NO)-L-arginine (LARG)-on hepatic lesions caused by ischemia/reperfusion (I/R) injury in rabbit livers. Rabbits were pretreated with LARG (150 mg/kg IV) or saline solution 0.9% (SS) before the hepatic I/R procedure. the effects of LARG on hepatic injury were evaluated before and after I/R. the warm hepatic I/R procedure produced profound acute liver injury, as indicated by elevated values of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactic dehydrogenase (LDH), as well as a high apoptotic cell count. All changes were attenuated by treatment with LARG before the hepatic I/R procedure. These results suggested that LARG produced protective effects on hepatic I/R lesions. This protective effect of LARG was probably associated with blocking generation of superoxide anions during the hepatic I/R procedure.
Transplantation Proceedings. New York: Elsevier B.V., v. 41, n. 3, p. 816-819, 2009.