Chronic lipoic acid treatment worsens energy imbalances in streptozotocin-induced diabetic rats

Chronic lipoic acid treatment worsens energy imbalances in streptozotocin-induced diabetic rats

Author Luz, J. Autor UNIFESP Google Scholar
Zemdegs, J. C. S. Autor UNIFESP Google Scholar
Amaral, L. S. G. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Aim. - Our objective was to verify the energy balance in streptozotocin-induced diabetic rats chronically treated with lipoic acid (LA).Methods. - Diabetes was induced in rats by streptozotocin and the animals divided into four groups, comprising controls and diabetic rats, with each group receiving either daily intraperitoneal LA (30 mg/kg) or a buffer solution for 30 days. Body weight, food intake and stool and urine collections were recorded daily. On day 30, animals were sacrificed and the carcasses, faeces and urine collected and processed for calorimetric analysis. Blood glucose and insulin were also determined.Results. - All parameters of energy balance were affected by diabetes. LA treatment reduced weight gain, energy gain and gross food efficiency in both control and diabetic animals. However, the LA-treated animals tended to show higher energy expenditure than non-treated animals. Body composition was also affected by diabetes: fat content was impaired by LA treatment in both control and diabetic animals. the latter also showed increased glycaemia and decreased insulinaemia, but LA had no effect on these parameters.Conclusion. - Our results indicate that chronic treatment with LA aggravates energy imbalances in diabetic animals. Moreover, our data suggest the need to reconsider the use of LA as an adjuvant in the prevention and treatment of type 1 diabetes. (C) 2008 Elsevier Masson SAS. All rights reserved.
Keywords Lipoic acid
Diabetes mellitus
Animal model of diabetes
Rat
Streptozotocin
Energy balance
Energy expenditure
Energy intake
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 02/09476-3
FAPESP: 03/03053-6
Date 2009-04-01
Published in Diabetes & Metabolism. Moulineaux Cedex 9: Masson Editeur, v. 35, n. 2, p. 137-142, 2009.
ISSN 1262-3636 (Sherpa/Romeo, impact factor)
Publisher Masson Editeur
Extent 137-142
Origin http://dx.doi.org/10.1016/j.diabet.2008.08.005
Access rights Closed access
Type Article
Web of Science ID WOS:000265673300009
URI http://repositorio.unifesp.br/handle/11600/31416

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