Influence of age on inducibility and cholinergic modulation of arrhythmia in isolated rat right atria

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dc.contributor.author Faria, D. M.
dc.contributor.author Viviane, A. G.
dc.contributor.author Galvao, K. M. [UNIFESP]
dc.contributor.author Caricati-Neto, A. [UNIFESP]
dc.contributor.author Godoy, C. M. G.
dc.date.accessioned 2016-01-24T13:52:19Z
dc.date.available 2016-01-24T13:52:19Z
dc.date.issued 2009-03-01
dc.identifier http://dx.doi.org/10.1007/s11357-008-9080-1
dc.identifier.citation Age. Dordrecht: Springer, v. 31, n. 1, p. 51-58, 2009.
dc.identifier.issn 0161-9152
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/31352
dc.description.abstract The effects of carbachol and atropine on the number of trains (NT) and on the train stimulus strength (SS) necessary to induce arrhythmia were studied in isolated right atria of infant, young, adult and mature rats submitted to electric field stimulation (66.7 Hz, 5 ms pulse-duration, 250 pulses). Carbachol (1 mu M) decreased NT from four (control) to two in all ages tested. Atropine (1 mu M) prevented tachyarrhythmia induction in tissue of all ages, even with NT equal to 12, except for mature rats (typically four trains). the SS decreases from infant to adult age [5- to 2-fold atrial threshold (AT)] and increases in mature animals (5-fold AT). Carbachol changes this result only for mature rats (5- to 2-fold AT). the SS was decreased by carbachol (1 mu M) from 5- to 3-fold AT in mature rats, but atropine did not modify SS in this age. These results indicate that inducibility and cholinergic modulation of atrial tachyarrhythmia is influenced by age. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship FAEP/UMC
dc.format.extent 51-58
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Age
dc.rights Acesso restrito
dc.subject Acetylcholine receptor en
dc.subject Age en
dc.subject Arrhythmia en
dc.subject Cardiac muscle en
dc.subject Cholinergic en
dc.title Influence of age on inducibility and cholinergic modulation of arrhythmia in isolated rat right atria en
dc.type Artigo
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution UMC
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation UMC, BR-08780911 Mogi Das Cruzes, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, EPM, Dept Pharmacol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, EPM, Dept Pharmacol, São Paulo, Brazil
dc.identifier.doi 10.1007/s11357-008-9080-1
dc.description.source Web of Science
dc.identifier.wos WOS:000263644800005



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