Maternal BMI and preterm birth: A systematic review of the literature with meta-analysis

Maternal BMI and preterm birth: A systematic review of the literature with meta-analysis

Author Torloni, Maria Regina Autor UNIFESP Google Scholar
Betran, Ana Pilar Google Scholar
Daher, Silvia Autor UNIFESP Google Scholar
Widmer, Mariana Google Scholar
Dolan, Siobhan M. Google Scholar
Menon, Ramkumar Google Scholar
Bergel, Eduardo Google Scholar
Allen, Tomas Google Scholar
Merialdi, Mario Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Albert Einstein Coll Med
Emory Univ
Abstract Objectives. To examine the association between high prepregnancy maternal body mass index (BMI) and the risk of preterm birth (PTB).Methods. A systematic review of the literature. We included cohorts and case-control studies published since 1968 that examined the association between BMI and PTB of all types, spontaneous (s), elective and with ruptured membranes (PPROM) in three gestational age categories: general (<37 weeks), moderate (32-36 weeks) and very (<32 weeks) PTB.Results. 20,401 citations were screened and 39 studies (1,788,633 women) were included. Preobese (BMI, 25-29.9) and obese I (BMI, 30-34.9) women have a reduced risk for sPTB: AOR - 0.85 (95% CI: 0.80-0.92) and 0.83 (95% CI: 0.75-0.92), respectively. Their risk for moderate PTB was 1.20 (95% CI: 1.04-1.38) and 1.60 (95% CI: 1.32-1.94), respectively. Obese II women (BMI, 35-40) have an increased risk for PTB in general (AOR = 1.33, 95% CI: 1.12-1.57) moderate (AOR - 2.43, 95% CI: 1.46-4.05) and very PTB (AOR - 1.96, 95% CI: 1.66-2.31). Obese III women (BMI > 40) have an even higher risk for very PTB (AOR = 2.27, 95% CI: 1.76-2.94). High BMI does not modify the risk for PPROM and increases the risk for elective PTB.Conclusions. High maternal BMI may have different effects on different types of PTB.
Keywords Body mass index
premature birth
preterm labor
literature review
Language English
Date 2009-01-01
Published in Journal of Maternal-fetal & Neonatal Medicine. Abingdon: Taylor & Francis Ltd, v. 22, n. 11, p. 957-970, 2009.
ISSN 1476-7058 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 957-970
Access rights Closed access
Type Review
Web of Science ID WOS:000270939400001

Show full item record


File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)




My Account