HIV-GB virus C co-infection: an overview

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Data
2009-01-01
Autores
Baggio-Zappia, Giovana Lotici [UNIFESP]
Hernandes Granato, Celso Francisco
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GB virus C (GBV-C) and hepatitis G virus (HGV) are two isolates of the same virus, independently identified in humans in the 1990s by two research laboratories, and were initially considered a potential cause of liver disease. Studies failed to associate the virus with hepatitis or any known human disease. GBV-C reappeared in the scientific scene when some research groups, in an attempt to find the interference of the virus among HIV seropositive patients, reported a lower mortality rate and slower disease progression among co-infected patients. From then on, several mechanisms have been proposed to clarify this putative benefit; however, the question whether GBV-C exerts a protective effect in HIV-infected patients remains to be resolved.
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Clinical Chemistry and Laboratory Medicine. Berlin: Walter de Gruyter & Co, v. 47, n. 1, p. 12-19, 2009.