Diversity of pathways for intracellular angiotensin II synthesis

Diversity of pathways for intracellular angiotensin II synthesis

Author Kumar, Rajesh Google Scholar
Boim, Mirian A. Autor UNIFESP Google Scholar
Institution Texas A&M Hlth Sci Ctr
Scott & White Mem Hosp & Clin
Cent Texas Vet Healthcare Syst
Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose of reviewThe renin-angiotensin system (RAS) has undergone continuous advancement since the initial identification of renin as a pressor agent. Traditionally considered a circulatory system, the RAS is now known to exist as a tissue system as well. Recently, the tissue RAS has been further categorized as intracellular and extracellular. Owing to the unique location, the intracellular RAS encompasses new components, such as cathepsin D and chymase, which participate in intracellular angiotensin (Ang) II synthesis. in this review, evidence of the intracellular RAS and the mechanism of Ang II synthesis in various cell types will be discussed.Recent findingsA physiological role for intracellular Ang II in vascular and cardiac cells has recently been demonstrated. Evidence of intracellular Ang II generation has been shown in several cell types, particularly cardiac, renal, and vascular. Importantly, intracellular synthesis of Ang II is more prominent in hyperglycemic conditions and generally involves angiotensin-converting enzyme-dependent and angiotensin-converting enzyme-independent mechanisms,SummaryThere is significant diversity in the mechanism of intracellular synthesis of Ang II in various cell types and pathological conditions. These observations suggest that a therapeutic intervention to block the RAS should take into consideration the nature of the disorder and the cell type involved.
Keywords angiotensin-converting enzyme
chymase
diabetes
intracrine
renin
renin-angiotensin system
Language English
Date 2009-01-01
Published in Current Opinion in Nephrology and Hypertension. Philadelphia: Lippincott Williams & Wilkins, v. 18, n. 1, p. 33-39, 2009.
ISSN 1062-4821 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 33-39
Origin http://dx.doi.org/10.1097/MNH.0b013e32831a9e20
Access rights Closed access
Type Review
Web of Science ID WOS:000262323300007
URI http://repositorio.unifesp.br/handle/11600/31204

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