Magnesium sulphate given topically by iontophoresis for viability of random skin flaps in rats

Magnesium sulphate given topically by iontophoresis for viability of random skin flaps in rats

Author Yu, Renato Andre Google Scholar
Brumini, Christine Google Scholar
Esteves Junior, Ivaldo Google Scholar
Ferreira, Lydia Masako Autor UNIFESP Google Scholar
Liebano, Richard Eloin Autor UNIFESP Google Scholar
Institution Univ Estadual Paulista
Univ Prebiteriana Mackenzie
Universidade Federal de São Paulo (UNIFESP)
Univ City São Paulo
Abstract Our aim was to assess the effects of magnesium sulphate given by iontophoresis on the viability of random skin flaps in rats. Endovenous magnesium sulphate is used to treat pre-eclampsia and diseases of blood vessels. Iontophoresis is an electrotherapeutic method which has shown satisfactory results in controlling ischaemia within the boundaries of the area in which it was given. Forty-five adult male Wistar rats, weighing 300 to 440 g were randomly divided into three groups of 15 animals each: random skin flap (control); random skin flap treated with magnesium sulphate without electrical stimulation; and random skin flap treated with magnesium sulphate with electrical stimulation of 4 mA for 20 minutes. the treatments were applied immediately after the operation and repeated on the following two days. the percentage of necrotic area was measured on the seventh postoperative day using a paper template. for each group, the mean percentage of flap necrosis was as follows: control, 46%; magnesium sulphate without electrical stimulation, 34%; and magnesium sulphate with electrical stimulation, 42%. There was no significant difference among the groups (p=0.18). Magnesium sulphate given by iontophoresis does not increase the viability of random skin flaps in rats.
Keywords Surgical flaps
ischemia
magnesium sulphate
iontophoresis
Language English
Date 2009-01-01
Published in Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery. Oslo: Taylor & Francis As, v. 43, n. 4, p. 197-200, 2009.
ISSN 0284-4311 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis As
Extent 197-200
Origin http://dx.doi.org/10.1080/02844310902840122
Access rights Closed access
Type Article
Web of Science ID WOS:000269068100002
URI http://repositorio.unifesp.br/handle/11600/31190

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