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dc.contributor.authorSartorelli, Patricia [UNIFESP]
dc.contributor.authorCarvalho, Camila Salomone
dc.contributor.authorReimao, Juliana Quero
dc.contributor.authorPena Ferreira, Marcelo Jose
dc.contributor.authorTempone, Andre Gustavo
dc.identifier.citationParasitology Research. New York: Springer, v. 104, n. 2, p. 311-314, 2009.
dc.description.abstractThe fractionation through bioguided antileishmanial activity of the dichloromethane extract of Cassia fistula fruits (Leguminosae) led to the isolation of the active isoflavone biochanin A, identified by spectroscopic methods. This compound showed 50% effective concentration (EC50) value of 18.96 mu g/mL against promastigotes of Leishmania (L.) chagasi. the cytotoxicity of this substance against peritoneal macrophages resulted in an EC50 value of 42.58 mu g/mL. Additionally, biochanin A presented an anti-Trypanosoma-cruzi activity, resulting in an EC50 value of 18.32 mu g/mL and a 2.4-fold more effectiveness than benznidazole. These results contribute with novel antiprotozoal compounds for future drug design studies.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipInstituto Adolfo Lutz
dc.relation.ispartofParasitology Research
dc.rightsAcesso restrito
dc.titleAntiparasitic activity of biochanin A, an isolated isoflavone from fruits of Cassia fistula (Leguminosae)en
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCtr Univ FIEO
dc.contributor.institutionAdolfo Lutz Inst
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ciencias Exatas & Terra, BR-09972270 São Paulo, Brazil
dc.description.affiliationCtr Univ FIEO, Ctr Estudos Quim, São Paulo, Brazil
dc.description.affiliationAdolfo Lutz Inst, Dept Parasitol, Lab Toxinol Aplicada, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Quim, Dept Quim Fundamental, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ciencias Exatas & Terra, BR-09972270 São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 01/05023-1
dc.description.sponsorshipIDInstituto Adolfo Lutz: CCD-BM 16/2004
dc.description.sourceWeb of Science

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