Antiparasitic activity of biochanin A, an isolated isoflavone from fruits of Cassia fistula (Leguminosae)
Sartorelli, Patricia [UNIFESP]
Carvalho, Camila Salomone
Reimao, Juliana Quero
Pena Ferreira, Marcelo Jose
Tempone, Andre Gustavo
Is part ofParasitology Research
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The fractionation through bioguided antileishmanial activity of the dichloromethane extract of Cassia fistula fruits (Leguminosae) led to the isolation of the active isoflavone biochanin A, identified by spectroscopic methods. This compound showed 50% effective concentration (EC50) value of 18.96 mu g/mL against promastigotes of Leishmania (L.) chagasi. the cytotoxicity of this substance against peritoneal macrophages resulted in an EC50 value of 42.58 mu g/mL. Additionally, biochanin A presented an anti-Trypanosoma-cruzi activity, resulting in an EC50 value of 18.32 mu g/mL and a 2.4-fold more effectiveness than benznidazole. These results contribute with novel antiprotozoal compounds for future drug design studies.
CitationParasitology Research. New York: Springer, v. 104, n. 2, p. 311-314, 2009.
SponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Instituto Adolfo Lutz
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