Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV

Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV

Author Inocencio, Lilian A. Google Scholar
Pereira, Anderson A. Google Scholar
Sucupira, Maria Cecilia A. Autor UNIFESP Google Scholar
Fernandez, Jose Carlos C. Google Scholar
Jorge, Celia P. Google Scholar
Souza, Denise F. C. Google Scholar
Fink, Helena T. Google Scholar
Diaz, Ricardo Sobhie Autor UNIFESP Google Scholar
Becker, Irina M. Google Scholar
Suffert, Theodoro A. Google Scholar
Arruda, Monica B. Google Scholar
Macedo, Olinda Google Scholar
Simao, Mariangela B. G. Google Scholar
Tanuri, Amilcar Google Scholar
Institution Universidade Federal do Rio de Janeiro (UFRJ)
Minist Hlth
Universidade Federal de São Paulo (UNIFESP)
IOC FIOCRUZ
Universidade Federal da Bahia (UFBA)
Publ Hlth Lab LACEN Brasilia
Publ Hlth Lab LACEN
Municipatil Porto Alegre
Abstract Use of antiretrovirals is widespread in Brazil, where more than 200,000 individuals are under treatment. Although general prevalence of primary antiretroviral resistance in Brazil is low, systematic sampling in large metropolitan areas has not being performed.The HIV Threshold Survey methodology (HIV-THS, WHO) was utilized, targeting Brazil's four major regions and selecting the six most populated state capitals: São Paulo, Rio de Janeiro, Salvador, Porto Alegre, Brasilia and Belem. We were able to sequence samples from 210 individuals with recent HIV diagnosis, 17 of them (8.1%) carrying HIV isolates with primary antiretroviral resistance mutations. Five, nine and four isolates showed mutations related to resistance to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs), respectively. Using HIV-THS, we could find an intermediate level of transmitted resistance (5% to 15%) in Belem/Brasilia, São Paulo and Rio de Janeiro. Lower level of transmitted resistance (<5%) were observed in the other areas. Despite the extensive antiretroviral exposure and high rates of virologic antiretroviral failure in Brazil, the general prevalence of primary resistance is still low. However, an intermediate level of primary resistance was found in the four major Brazilian cities, confirming the critical need to start larger sampling surveys to better define the risk factors associated with transmission of resistant HIV.
Language English
Sponsor Brazilian Ministry of Health
UNESCO
UNDOC
Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2009-01-01
Published in Journal of the International Aids Society. London: Biomed Central Ltd, v. 12, 6 p., 2009.
ISSN 1758-2652 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 6
Origin http://dx.doi.org/10.1186/1758-2652-12-20
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000208106500020
URI http://repositorio.unifesp.br/handle/11600/31121

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