Novel Perspectives of Neural Stem Cell Differentiation: From Neurotransmitters to Therapeutics

Nenhuma Miniatura disponível
Data
2009-01-01
Autores
Trujillo, Cleber A.
Schwindt, Telma Tiemi [UNIFESP]
Martins, Antonio Henrique Baccin [UNIFESP]
Alves, Janaina Maria [UNIFESP]
Mello, Luiz Eugenio Araujo de Moraes [UNIFESP]
Ulrich, Henning
Orientadores
Tipo
Resenha
Título da Revista
ISSN da Revista
Título de Volume
Resumo
In the past years, many reports have described the existence of neural progenitor and stem cells in the adult central nervous system capable of generating new neurons, astrocytes, and oligodendrocytes. This discovery has overturned the central assumption in the neuroscience field, of no new neurons being originated in the brain after birth and provided the fundaments to understand the molecular basis of neural differentiation and to develop new therapies for neural tissue repair. Although the mechanisms underlying cell fate during neural development are not yet understood, the importance of intrinsic and extrinsic factors and of an appropriate microenvironment is well known. in this context, emerging evidence strongly suggests that glial cells play a key role in controlling multiple steps of neurogenesis. Those cells, of particular radial glia, are important for migration, cell specification, and integration of neurons into a functional neural network. This review aims to present an update in the neurogenesis area and highlight the modulation of neural stem cell differentiation by neurotransmitters, growth factors, and their receptors, with possible applications for cell therapy strategies of neurological disorders. (C) 2008 international Society for Advancement of Cytometry
Descrição
Citação
Cytometry Part A. Hoboken: Wiley-liss, v. 75A, n. 1, p. 38-53, 2009.