Angiogenesis and growth factor modulation induced by altelnagin C, a snake venom disintegrin-like, cysteine-rich protein on a rat skin wound model
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2008-11-01
Autores
Correia St Ana, Estela Maria
Cacao Paiva Gouvea, Cibele Marli
Nakaie, Clovis Ryuichi [UNIFESP]
Selistre-de-Araujo, Heloisa Sobreiro
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In this work, we show that alternagin-C (ALT-C) and ALT-C PEP, a peptide derived from its sequence, were able to induce angiogenesis ill Wounded rat skin. A spherical Cutaneous excision was made in the back of each animal and treated with three different concentrations of ALT-C or ALT-C PEP. After that, the skin was removed and analyzed to verify the presence of new vessels and the expression of growth factors. ALT-C and ALT-C PEP induced the formation of new vessels and modulated the expression of growth factors, mainly VEGF and FGH. the expression of VEGF increased and it Could be detected Up to 7 days after injury. FGH also significantly increased, but at a lesser extent than VEGF. in conclusion, the present Study shows for the first time the stimulation of angiogenesis in an injured tissue by a disintegrin-like protein and that ALT-C may exert this effect by modulating the expression of growth factors.(c) 2008 Elsevier Inc. All rights reserved.
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Archives of Biochemistry and Biophysics. New York: Elsevier B.V., v. 479, n. 1, p. 20-27, 2008.