Plasmid-mediated quinolone resistance in Aeromonas allosaccharophila recovered from a Swiss lake
Picão, Renata Cristina [UNIFESP]
Ferreira Silva, Carla Sofia
Rita Corvaglia, Anna
Es parte deJournal of Antimicrobial Chemotherapy
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Objectives: To search for plasmid-mediated qnr genes among waterborne environmental Aeromonas spp. recovered from Switzerland.Methods: Isolates presenting MICs of nalidixic acid or ciprofloxacin >= 1 mg/L were screened for qnr genes by a multiplex PCR approach followed by sequencing. Plasmids were transferred by transformation, and further analysis of the genetic structures surrounding the qnrS2 gene was carried out by PCR and sequencing.Results: A qnrS2 gene was identified from a single Aeromonas allosaccharophila isolate (Lugano lake, Lugano), as part of a mobile insertion cassette located on a broad host range IncU-type plasmid. This plasmid co-harboured a class 1 integron containing the aac(6 ')-Ib-cr, bla(OXA-1), catB3 and arr-3 gene cassettes.Conclusions: These findings strengthen further the role of Aeromonas spp. as a reservoir of antimicrobial resistance determinants in the environment.
CitaJournal of Antimicrobial Chemotherapy. Oxford: Oxford Univ Press, v. 62, n. 5, p. 948-950, 2008.
ResponsávelMinistere de l'Education Nationale et de la Recherche
Universite Paris XI, France
Swiss National Science Foundation
National Research Program 'Antibiotic resistance'
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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