Bcl-2 and Bax expressions in pre-term, term and post-term placentas

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Daher, Silvia [UNIFESP]
Guimaraes, Alberto Jorge de Sousa [UNIFESP]
Mattar, Rosiane [UNIFESP]
Ishigai, Marcia Marcelino de Souza [UNIFESP]
Barreiro, Erica Giovana [UNIFESP]
Bevilacqua, Estela Maris Andrade Forell [UNIFESP]
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ProblemPlacental apoptosis-associated protein imbalance might contribute to the pathogenesis of pre- and post-term birth. Therefore, we evaluated the expression and distribution of pro-apoptotic (Bax) and anti-apoptotic (Bcl-2) molecules in term, pre-term and post-term placentas.Method of StudyPlacental samples were collected from women with term (n = 25), pre-term (n = 7) and post-term (n = 10) deliveries. the expression of Bcl-2 and Bax was assessed by immunochemistry on paraffin-embedded placental specimens.ResultsThe pattern of immunostaining for Bcl-2 and Bax was the same in all samples, but not the intensity. the Bax/Bcl-2 ratio was higher in both pre-term and post-term placental samples compared with term placentas as a result of intense reactivity for the pro-apoptotic factor, Bax in pre-term and post-term placentas and, for Bcl-2 decrease in pre-term placentas.ConclusionThese findings suggest that different unbalance mechanisms in placental apoptotic-associated protein expressions may be involved in the physiopathology of pre-term and post-term births.
American Journal of Reproductive Immunology. Malden: Wiley-Blackwell, v. 60, n. 2, p. 172-178, 2008.