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dc.contributor.authorFioretto, Jose R.
dc.contributor.authorMartin, Joelma G.
dc.contributor.authorKurokawa, Cilmery S.
dc.contributor.authorCarpi, Mario F.
dc.contributor.authorBonatto, Rossano C.
dc.contributor.authorRicchetti, Sandra M. Q.
dc.contributor.authorMoraes, Marcos A. de
dc.contributor.authorPadovani, Carlos R.
dc.identifier.citationCytokine. London: Academic Press Ltd Elsevier B.V., v. 43, n. 2, p. 160-164, 2008.
dc.description.abstractObjectives. To examine the behavior of interleukin-6 (IL-6) and procalcitonin (PCT) and verify whether they can be used to differentiate children with septic conditions. Methods. Septic children aged between 28 days and 14 years, prospectively enrolled from 01/2004 to 12/2005, were divided into sepsis (SG; n = 47) and septic shock (SSG; n = 43) groups. IL-6 and PCT were measured at admission (TO) and 12 h later (T12h). PCT results were classed as: 0.5 ng/mL = sepsis unlikely; >= 0.5 to < 2 = sepsis possible; >= 2 to < 10 = systemic inflammation: >= 10 = septic shock. Results. Ninety children were included. At TO, there was a higher frequency of SSG with higher PCT compared with SG [SSG: 30 (69.7%) > SG: 14 (29.8%): p < 0.051. Similar results were observed at T12h. PRISM was significantly higher for SSG patients with higher PCT than SG patients. At TO, IL-6 levels were higher in SSG [SSG: 213.10 (10.85-396.70) > SG: 63.21 (0.86-409.82); p = 0.001], but not statistically different at T12h. IL-6 levels positively correlated with PRISM score in SSG patients at admission (p = 0.001; r = 0.86). Conclusion. PCT and IL-6 appear to be helpful in early assessment of pediatric sepsis, are of diagnostic value at admission, and are related to disease severity. (c) 2008 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.publisherElsevier B.V.
dc.rightsAcesso restrito
dc.subjectseptic shocken
dc.titleInterleukin-6 and procalcitonin in children with sepsis and septic shocken
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSão Paulo State Univ UNESP
dc.description.affiliationSão Paulo State Univ UNESP, Botucatu Med Sch, Dept Pediat, Pediat Intens Care Unit, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Expt Res Ctr, Dept Pediat, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Botucatu Inst Biosci, Dept Biosci, São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 04/03776-0
dc.description.sourceWeb of Science

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