Psychiatric comorbidity in epilepsy: A study comparing patients with mesial temporal sclerosis and juvenile myoclonic epilepsy

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Araujo Filho, Gerardo Maria de [UNIFESP]
Rosa, Vivianne Pellegrino [UNIFESP]
Lin, Katia [UNIFESP]
Sales Ferreira Caboclo, Luis Otavio [UNIFESP]
Sakamoto, Americo Ceiki [UNIFESP]
Targas Yacubian, Elza Marcia [UNIFESP]
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We evaluated the frequency of psychiatric disorders (PDs) in a homogenous series of patients with temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS), as compared with patients with juvenile myoclonic epilepsy (JME), aiming to determine possible differences in psychiatric diagnoses between these two epileptic syndromes. Data from 170 patients with refractory TLE-MTS and from 100 patients with JME were reviewed and compared. the prevalence of PDs was high in both groups of patients with epilepsy: PDs were present in 85 patients with TLE-MTS (50%) and 49 patients with JME (49%). Among the TLE-MTS group, mood (25.8%), psychotic (15.8%), and anxiety (14.1%) disorders were the most frequent diagnoses, whereas anxiety and mood disorders (23 and 19%, respectively) were the most common among patients with JME. Psychoses were significantly associated with NITS (P < 0.01) and anxiety disorders with JME (P < 0.05). These findings suggest the existence of an anatomic correlation between PDs and brain structures involved in both epilepsy syndromes. (c) 2008 Elsevier Inc. All rights reserved.
Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 13, n. 1, p. 196-201, 2008.