Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus

Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus

Author Persike, Daniele Suzete Autor UNIFESP Google Scholar
Oliveira Rodrigues Cunha, Rodrigo Luiz Autor UNIFESP Google Scholar
Juliano, Luiz Autor UNIFESP Google Scholar
Silva, Lara Ribeiro Autor UNIFESP Google Scholar
Rosim, Fernanda Elisa Autor UNIFESP Google Scholar
Vignoli, Thiago Autor UNIFESP Google Scholar
Doná, Flávia Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Silva Fernandes, Maria Jose da Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Temporal lobe epilepsy is the most common form of epilepsy in humans. Caspase activation is a mechanism of cell death induced by seizures. Tellurium (IV) compounds present antitumoral, immunomodulatory and neuroprotective effects due to their ability to inhibit cysteine proteases. We studied the activity of caspase-1, -3 and -8 in the hippocampus of rats exhibiting status epilepticus induced by pilocarpine. All three caspases were activated. Tellurium (IV) compounds RF-07, RF-03 and AS-101 inhibited caspases in vitro, showing high second-order inhibition rate constants. the intraperitoneal injection of RF-07 prior to pilocarpine suppressed the behavioral and electroencephalographic seizure occurrence. According to our results, the caspases are activated as early as 90 min following SE. Tellurium (IV) compounds exerted anticonvulsant effects associated with the inhibition of caspases. These results suggest a promising therapeutic potential of organotellurium (IV) compounds as antiepileptogenic agents. (C) 2008 Elsevier Inc. All rights reserved.
Language English
Date 2008-07-01
Published in Neurobiology of Disease. San Diego: Academic Press Inc Elsevier Science, v. 31, n. 1, p. 120-126, 2008.
ISSN 0969-9961 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 120-126
Access rights Closed access
Type Article
Web of Science ID WOS:000257217100012

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