Effects of hexestrol on mouse ovarian morphology and ovulation

Effects of hexestrol on mouse ovarian morphology and ovulation

Author Oliveira, Joaquim Moraes de Autor UNIFESP Google Scholar
Simoes, Manuel J. Autor UNIFESP Google Scholar
Mora, Oswaldo Alves Autor UNIFESP Google Scholar
Simoes, Ricardo Santos Autor UNIFESP Google Scholar
Oliveira-Filho, Ricardo M. Autor UNIFESP Google Scholar
Oliveira, Patricia B. Autor UNIFESP Google Scholar
Baracat, Edmund C. Autor UNIFESP Google Scholar
Soares, Jose Maria Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: To analyze histological aspects of ovaries as well as the ovulation of adult mice treated with the anabolic agent hexestrol.Methods: Thirty adult mice were divided into three groups of 10 animals each: (GI) the animals received a dose of 3 mg/kg of hexestrol; (GII) the animals were given a dose of 6 mg/kg of hexestrol; (GIII) the animals were injected with distilled water (vehicle). Another 10-animal group (GIV) was included, and these mice were injected with propionate testosterone (1.25 mg) after 5 days from the day of birth. Hexestrol was administered intraperitoneally once a day and the treatment lasted 30 days. the mice were then sacrificed; their ovaries and oviducts were removed, submitted to histological routine and analyzed under light microscopy.Results: in mice treated with hexestrol (6 mg/kg) (Group II), ovaries were smaller than those from the controls but highly vascularized; similar results were obtained in GIV. A great number of follicles in several stages of development were found however, with no corpora lutea - in six animals in GII No corpora lutea were found in GIV. the number of luteal bodies and oocytes in GII was lower than that in GI or GIII. No oocytes were detected in GIV. Finally, the nuclear volume of interstitial cells in GII and GIV was the largest.Conclusion: Our data suggest that the anabolic agent hexestrol in a high dose may decrease ovulation in mice. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Keywords hexestrol
Language English
Date 2008-06-20
Published in Maturitas. Clare: Elsevier B.V., v. 60, n. 2, p. 153-157, 2008.
ISSN 0378-5122 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 153-157
Origin http://dx.doi.org/10.1016/j.maturitas.2008.05.002
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000258048700009
URI http://repositorio.unifesp.br/handle/11600/30735

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