• RI - Unifesp
    • Documentos
    • Tutoriais
    • Perguntas frequentes
    • Atendimento
    • Equipe
    • português (Brasil)
    • English
    • español
  • Sobre
    • RI Unifesp
    • Documentos
    • Tutoriais
    • Perguntas frequentes
    • Atendimento
    • Equipe
  • English 
    • português (Brasil)
    • English
    • español
    • português (Brasil)
    • English
    • español
  • Login
View Item 
  •   DSpace Home
  • UNIFESP
  • Unifesp - Em verificação
  • Em verificação - Geral
  • View Item
  •   DSpace Home
  • UNIFESP
  • Unifesp - Em verificação
  • Em verificação - Geral
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Hemiparkinsonian rats rotate toward the side with the weaker dopaminergic neurotransmission

Thumbnail
Date
2008-06-03
Author
Da Cunha, Claudio
Wietzikoski, Evellyn Claudia
Ferro, Marcelo Machado
Martinez, Glaucia Regina
Barbato Frazao Vital, Maria Aparecida
Hipolide, Debora [UNIFESP]
Tufik, Sergio [UNIFESP]
Canteras, Newton Sabino
Type
Artigo
ISSN
0166-4328
Is part of
Behavioural Brain Research
DOI
10.1016/j.bbr.2008.01.012
Metadata
Show full item record
Abstract
Rats with unilateral lesion of the substantia nigra pars compacta (SNpc) have been used as a model of Parkinson's disease. Depending on the lesion protocol and on the drug challenge, these rats rotate in opposite directions. the aim of the present study was to propose a model to explain how critical factors determine the direction of these turns. Unilateral lesion of the SNpc was induced with 6-hydroxydopamine (6-OHDA) or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Separate analysis showed that neither the type of neurotoxin nor the site of lesion along the nigrostriatal. pathway was able to predict the direction of the turns these rats made after they were challenged with apomorphine. However, the combination of these two factors determined the magnitude of the lesion estimated by tyrosine-hydroxylase immunohistochemistry and HPLC-ED measurement of striatal dopamine. Very small lesions did Dot cause turns, medium-size lesions caused ipsiversive turns, and large lesions caused contraversive turns. Large-size SNpc lesions resulted in an increased binding of [H-3] raclopride to D2 receptors, while medium-size lesions reduced the binding of [H-3]SCH-23390 D1 receptors in the ipsilateral striatum. These results are coherent with the model proposing that after challenged with a dopamine receptor agonist, unilaterally SNpc-lesioned rats rotate toward the side with the weaker activation of dopamine receptors. This activation is weaker on the lesioned side in animals with small SNpc lesions due to the loss of dopamine, but stronger in animals with large lesions due to dopamine receptor supersensitivity. (C) 2008 Elsevier B.V. All rights reserved.
Citation
Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 189, n. 2, p. 364-372, 2008.
Keywords
substantia nigra pars compacta
turning behaviour
dopamine
basal ganglia
dopamine receptor
Parkinson's disease
MPTP
6-hydroxydopamine
URI
http://repositorio.unifesp.br/handle/11600/30726
Collections
  • Em verificação - Geral [10974]

DSpace software copyright © 2002-2016  DuraSpace
Contact Us
Theme by 
Atmire NV
 

 

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsBy Submit DateThis CollectionBy Issue DateAuthorsTitlesSubjectsBy Submit Date

My Account

Login

Statistics

View Usage Statistics

DSpace software copyright © 2002-2016  DuraSpace
Contact Us
Theme by 
Atmire NV