Obsessive-compulsive disorder: Influence of age at onset on comorbidity patterns

Obsessive-compulsive disorder: Influence of age at onset on comorbidity patterns

Author Mathis, Maria Alice de Google Scholar
Rosario, Maria Conceicao do Autor UNIFESP Google Scholar
Diniz, Juliana Belo Google Scholar
Torres, Albina Rodrigues Google Scholar
Shavitt, Roseli Gedanki Google Scholar
Ferrao, Ygor Arzeno Google Scholar
Fossaluza, Victor Google Scholar
Braganca Pereira, Carlos Alberto de Google Scholar
Miguel, Euripedes Constantino Google Scholar
Institution Universidade de São Paulo (USP)
Porto Alegre Inst Univ Ctr
Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose. - This study investigates the influence of age at onset of OCS on psychiatric comorbidities, and tries to establish a cut-off point for age at onset.Methods. - Three hundred and thirty OCD patients were consecutively recruited and interviewed using the following structured interviews: Yale-Brown Obsessive Compulsive Scale; Yale Global Tic Severity Scale and the Structured Clinical Interview for DSM-IV. Data were analyzed with regression and cluster analysis.Results. - Lower age at onset was associated with a higher probability of having comorbidity with tic, anxiety, somatoform, eating and impulse-control disorders. Longer illness duration was associated with lower chance of having tics. Female gender was associated with anxiety, eating and impulse-control disorders. Tic disorders were associated with anxiety disorders and attention-deficit/hyperactivity disorder. No cutoff age at onset was found to clearly divide the sample in homogeneous subgroups. However, cluster analyses revealed that differences started to emerge at the age of 10 and were more pronounced at the age of 17, suggesting that these were the best cut-off points on this sample.Conclusions. - Age at onset is associated with specific comorbidity patterns in OCD patients. More prominent differences are obtained when analyzing age at onset as an absolute value. (C) 2008 Elsevier Masson SAS. All rights reserved.
Keywords obsessive-compulsive disorder
age at onset
early onset
late onset
Language English
Date 2008-04-01
Published in European Psychiatry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 23, n. 3, p. 187-194, 2008.
ISSN 0924-9338 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 187-194
Origin http://dx.doi.org/10.1016/j.eurpsy.2008.01.002
Access rights Closed access
Type Article
Web of Science ID WOS:000254884100004
URI http://repositorio.unifesp.br/handle/11600/30564

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