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dc.contributor.authorFranco, Maria do Carmo Pinho [UNIFESP]
dc.contributor.authorCasarini, Dulce Elena [UNIFESP]
dc.contributor.authorCarneiro-Ramos, Marcella S.
dc.contributor.authorSawaya, Ana Lydia [UNIFESP]
dc.contributor.authorBarreto-Chaves, Maria Luiza M.
dc.contributor.authorSesso, Ricardo de Castro Cintra [UNIFESP]
dc.date.accessioned2016-01-24T13:49:35Z
dc.date.available2016-01-24T13:49:35Z
dc.date.issued2008-03-01
dc.identifierhttps://dx.doi.org/10.1042/CS20070284
dc.identifier.citationClinical Science. London: Portland Press Ltd, v. 114, n. 5-6, p. 375-380, 2008.
dc.identifier.issn0143-5221
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/30455
dc.description.abstractThere have been only a few reports on the sympathoadrenal and renin-angiotensin systems in children of small gestational age. the purpose of the present study was to investigate plasma levels of ACE (angiotensin-converting enzyme) activity, angiotensin and catecholamines in 8- to 13-year-old children and to determine whether there are correlations between the components of these systems with both birthweight and BP (blood pressure) levels. This clinical study included 66 children (35 boys and 31 girls) in two groups: those born at term with an appropriate birthweight [AGA (appropriate-for-gestational age) group, n = 31] and those born at term but with a small birthweight for gestational age [SGA (small-for-gestational age) group, n = 35]. Concentrations of angiotensin, catecholamines and ACE activity were determined in plasma. Circulating noradrenaline levels were significantly elevated in SGA girls compared with AGA girls (P = 0.036). in addition, angiotensin 11 and ACE activity were higher in SGA boys (P = 0.024 and P = 0.050 respectively). There was a significant association of the circulating levels of both angiotensin 11 and ACE activity with BP levels in our study population. Although the underlying mechanisms that link restricted fetal growth with later cardiovascular events are not fully understood, the findings in the present study support the link between low birthweight and overactivity of both sympathoadrenal and renin-angiotensin systems into later childhood.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.format.extent375-380
dc.language.isoeng
dc.publisherPortland Press Ltd
dc.relation.ispartofClinical Science
dc.rightsAcesso aberto
dc.subjectAngiotensin IIen
dc.subjectAngiotensin-converting enzyme (ACE) activityen
dc.subjectBirthweighten
dc.subjectBlood pressureen
dc.subjectNoradrenalineen
dc.subjectSmall-for-gestational ageen
dc.titleCirculating renin-angiotensin system and catecholamines in childhood: is there a role for birthweight?en
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniversidade Federal de São Paulo, Sch Med, Div Nephrol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sch Med, Div Nephrol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, BR-04023900 São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 04/10342-7pt
dc.description.sponsorshipIDFAPESP: 04/01672-3pt
dc.identifier.doi10.1042/CS20070284
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000253849000003


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