Long lasting alteration in REM sleep of female rats submitted to long maternal separation

Long lasting alteration in REM sleep of female rats submitted to long maternal separation

Author Tiba, Paula Ayako Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Suchecki, Deborah Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Early adverse experiences represent risk factors for the development of anxiety and mood disorders. Maternal separation can induce biobehavioral alterations in male rodents similar to those seen in depressed humans, such as hyperresponsiveness to stress and sleep disturbances. Nonetheless, no study has yet explored the effects of early life events on the relationship between stress and sleep in female rats. Whole litters of Wistar rats were submitted to brief- or long maternal separations (15 [BMS] or 180 min/day [LMS], from postnatal days 2-14) or kept undisturbed with their mothers (CTL). When adults, female rats were sleep-recorded for 22 h before (baseline) and after a 1 h exposure to cold stress (post-stress). Additional subsets of animals were sacrificed before, 1 or 3 h after the stressor for plasma corticosterone determination. No differences in baseline sleep were observed among the groups. Female rats submitted to LMS exhibited a significant increase of REM sleep on the night following a 1 h exposure to cold stress, whereas the sleep of BMS rats was barely altered by stress. All groups exhibited similar basal and stress-induced corticosterone levels. the present results are compared to a previous study performed in male rats, and corroborate that manipulations applied during infancy modify the expression of stress-induced sleep rebound. (C) 2007 Elsevier Inc. All rights reserved.
Keywords maternal separation
sleep rebound
REM sleep
HPA axis
Language English
Date 2008-02-27
Published in Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 93, n. 3, p. 444-452, 2008.
ISSN 0031-9384 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 444-452
Origin http://dx.doi.org/10.1016/j.physbeh.2007.10.001
Access rights Closed access
Type Article
Web of Science ID WOS:000253927400003
URI http://repositorio.unifesp.br/handle/11600/30451

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