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dc.contributor.authorDe Deus, Rogério Barbosa [UNIFESP]
dc.contributor.authorTeixeira, Vicente de Paulo Castro [UNIFESP]
dc.contributor.authorKirsztajn, Gianna Mastroianni [UNIFESP]
dc.identifier.citationNephron Clinical Practice. Basel: Karger, v. 110, n. 3, p. C164-C171, 2008.
dc.description.abstractBackground: Early diagnosis of proximal tubular lesions can be achieved by detecting abnormal levels of low molecular weight proteins in urine. Material and Methods: 100 cases of glomerulopathies were retrospectively studied to establish the profile of urinary levels of retinol-binding protein (urRBP) and their correlation with histological markers of tubulointerstitial lesions in renal biopsies. the histological study included staining with picrosirius red. Results: Non-proliferative glomerulopathies, male sex, white race and young adults were predominant. the chance of abnormal urRBP occurring was higher among patients with a predominant proliferative component, baseline serum creatinine >1.2 mg/dl (p = 0.008), creatinine clearance <70 ml/min (p = 0.006), and severe interstitial fibrosis (p = 0.042). in multivariate analysis, only serum creatinine and creatinine clearance were independently associated to urRBP, and only urRBP was a time-independent prognostic factor for survival without renal failure ( risk of renal failure: 9 !). Conclusion: Our study suggests that urRBP determination is prognostically relevant in the progression of glomerulopathies; on the other hand, the evaluated morphometric markers correlated poorly with the clinical outcome of these patients. Consequently, urRBP determination, as a functional marker of tubulointerstitial damage, was more appropriate for determining the prognosis of glomerular diseases than the morphometric analysis of renal biopsies. Copyright (C) 2008 S. Karger AG, Baselen
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.relation.ispartofNephron Clinical Practice
dc.rightsAcesso restrito
dc.subjectGlomerular diseaseen
dc.subjectRenal disease, progressionen
dc.subjectRetinol-binding proteinen
dc.subjectTubulointerstitial damageen
dc.titleRelative Contribution of Morphometric and Functional Indicators of Tubulointerstitial Lesion to Glomerular Diseases Prognosisen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade Federal de São Paulo, Serv Nephrol, EPM, Div Nephrol,Glomerulopathy & Renal Immunopathy Se, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Serv Nephrol, EPM, Div Nephrol,Glomerulopathy & Renal Immunopathy Se, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science

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