Hepatitis C among predialysis patients: Prevalence and characteristics in a large cohort of patients

Hepatitis C among predialysis patients: Prevalence and characteristics in a large cohort of patients

Author Lemos, Lara B. Autor UNIFESP Google Scholar
Perez, Renata M. Autor UNIFESP Google Scholar
Lemos, Marcelo M. Autor UNIFESP Google Scholar
Draibe, Sergio A. Autor UNIFESP Google Scholar
Souza e Silva, Ivonete Sandra de Autor UNIFESP Google Scholar
Silva, Antonio Eduardo B. Autor UNIFESP Google Scholar
Ferraz, Maria Lucia G. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: the factors associated with hepatitis C virus (HCV) infection in predialysis patients need to be better investigated. the aims of this study were to evaluate the prevalence, risk factors, clinical, biochemical and virological characteristics of chronic HCV infection in predialysis patients. Methods: Anti-HCV antibodies were determined in a large cohort of predialysis patients. Epidemiological and laboratorial characteristics of HCV infection were evaluated in predialysis patients and this group was matched to a control group consisting of predialysis patients without viral infection ( 1: 3) and compared in terms of risk factors and alanine aminotransferase (ALT) levels. Logistic regression analysis was applied to identify variables independently associated with chronic HCV infection. Results: A total of 1,041 patients (61% males) with a mean age of 61 +/- 15 years and mean creatinine clearance of 36 +/- 18 ml/min were included. Forty-one (3.9%) patients were anti-HCV positive and, of these, 39 (95%) presented viremia. Predialysis patients with HCV more frequently showed a history of blood transfusion before 1992 (66.7 vs. 10.3%; p < 0.001) and major surgeries (53.8 vs. 17.1%; p < 0.001), a higher proportion of undetermined etiology of kidney disease (43.6 vs. 17.1%; p = 0.001), and higher ALT levels (1.3 vs. 0.4 x ULN; p < 0.001). History of blood transfusion before 1992 (p < 0.001; OR: 19), intravenous drug abuse (p = 0.002; OR: 69) and ALT levels (p < 0.001; OR: 50) were the variables that were independently associated with chronic HCV infection. the accuracy of ALT in detecting HCV infection was 92%. the most prevalent HCV genotype was 1b (48.7%) and 56.5% of patients presented high HCV viral load. Conclusion: Chronic HCV infection among predialysis patients is related to increased parenteral exposure. Elevated ALT levels suggest the need for HCV screening as part of the predialysis care since ALT seems to be a good marker of this infection. Copyright (C) 2008 S. Karger AG, Basel.
Keywords hepatitis C virus
chronic renal disease
predialysis
prevalence
alanine aminotransferase
liver enzymes
Language English
Date 2008-01-01
Published in Nephron Clinical Practice. Basel: Karger, v. 108, n. 2, p. C135-C140, 2008.
ISSN 1660-2110 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent C135-C140
Origin http://dx.doi.org/10.1159/000114452
Access rights Closed access
Type Article
Web of Science ID WOS:000253247200008
URI http://repositorio.unifesp.br/handle/11600/30351

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account