Experimental paracoccidioidomycosis: alternative therapy with ajoene, compound from Allium sativum, associated with sulfamethoxazole/trimethoprim

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dc.contributor.author Thomaz, L.
dc.contributor.author Apitz-Castro, R.
dc.contributor.author Marques, A. F.
dc.contributor.author Travassos, L. R. [UNIFESP]
dc.contributor.author Taborda, Carlos Pelleschi [UNIFESP]
dc.date.accessioned 2016-01-24T13:49:26Z
dc.date.available 2016-01-24T13:49:26Z
dc.date.issued 2008-01-01
dc.identifier http://dx.doi.org/10.1080/13693780701651681
dc.identifier.citation Medical Mycology. Abingdon: Taylor & Francis Ltd, v. 46, n. 2, p. 113-118, 2008.
dc.identifier.issn 1369-3786
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30333
dc.description.abstract Ajoene has been described as an antithrombotic, anti-tumour, antifungal, antiparasitic and antibacterial agent. This study deals with the efficacy of ajoene to treat mice intratracheally infected with Paracoccidioides brasiliensis. the results indicate that ajoene therapy is effective in association with antifungal drugs (sulfametoxazol/trimethoprim), showing a positive additive effect. Ajoene-treated mice developed Th1-type cytokine responses producing higher levels of IFN-gamma and IL-12 when compared to the infected but untreated members of the control group. Antifungal activity of ajoene involves a direct effect on fungi and a protective pro-inflammatory immune response. Reduction of fungal load is additive to chemotherapy and therefore the combined treatment is mostly effective against experimental paracoccidioidomycosis. en
dc.format.extent 113-118
dc.language.iso eng
dc.publisher Taylor & Francis Ltd
dc.relation.ispartof Medical Mycology
dc.rights Acesso restrito
dc.subject Paracoccidioides brasiliensis en
dc.subject chemotherapy en
dc.subject Ajoene en
dc.subject Allium sativum en
dc.subject sulfamethoxazole/trimethoprim en
dc.title Experimental paracoccidioidomycosis: alternative therapy with ajoene, compound from Allium sativum, associated with sulfamethoxazole/trimethoprim en
dc.type Artigo
dc.rights.license http://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Inst Venezolano Invest Cient
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ São Paulo, Dept Microbiol, Inst Biomed Sci, BR-05508 São Paulo, Brazil
dc.description.affiliation Inst Venezolano Invest Cient, Lab Trombosis Expt, Ctr Biofis & Bioquim, Caracas, Venezuela
dc.description.affiliation Universidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.identifier.doi 10.1080/13693780701651681
dc.description.source Web of Science
dc.identifier.wos WOS:000253763300002



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