Experimental paracoccidioidomycosis: alternative therapy with ajoene, compound from Allium sativum, associated with sulfamethoxazole/trimethoprim

Experimental paracoccidioidomycosis: alternative therapy with ajoene, compound from Allium sativum, associated with sulfamethoxazole/trimethoprim

Author Thomaz, L. Google Scholar
Apitz-Castro, R. Google Scholar
Marques, A. F. Google Scholar
Travassos, L. R. Autor UNIFESP Google Scholar
Taborda, Carlos Pelleschi Autor UNIFESP Google Scholar
Institution Universidade de São Paulo (USP)
Inst Venezolano Invest Cient
Universidade Federal de São Paulo (UNIFESP)
Abstract Ajoene has been described as an antithrombotic, anti-tumour, antifungal, antiparasitic and antibacterial agent. This study deals with the efficacy of ajoene to treat mice intratracheally infected with Paracoccidioides brasiliensis. the results indicate that ajoene therapy is effective in association with antifungal drugs (sulfametoxazol/trimethoprim), showing a positive additive effect. Ajoene-treated mice developed Th1-type cytokine responses producing higher levels of IFN-gamma and IL-12 when compared to the infected but untreated members of the control group. Antifungal activity of ajoene involves a direct effect on fungi and a protective pro-inflammatory immune response. Reduction of fungal load is additive to chemotherapy and therefore the combined treatment is mostly effective against experimental paracoccidioidomycosis.
Keywords Paracoccidioides brasiliensis
chemotherapy
Ajoene
Allium sativum
sulfamethoxazole/trimethoprim
Language English
Date 2008-01-01
Published in Medical Mycology. Abingdon: Taylor & Francis Ltd, v. 46, n. 2, p. 113-118, 2008.
ISSN 1369-3786 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 113-118
Origin http://dx.doi.org/10.1080/13693780701651681
Access rights Closed access
Type Article
Web of Science ID WOS:000253763300002
URI http://repositorio.unifesp.br/handle/11600/30333

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