Quantitative determination of nadolol in tablets by high-performance liquid chromatography and UV-derivative spectrophotometry

Data
2008-01-01
Autor(a)
Tsubone, Camila [UNIFESP]
Garcia, Pedro Lopez [UNIFESP]
Gomes, Fabio Pereira [UNIFESP]
Maria Kedor-Hackmann, Erika Rosa [UNIFESP]
Rocha Miritello Santoro, Maria Ines [UNIFESP]
Tipo
Artigo
ISSN
0003-2719
É parte de
Analytical Letters
DOI
10.1080/00032710701689057
Metadado
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Resumo
High-performance liquid chromatographic (HPLC) and UV derivative spectrophotometric (UVDS) methods were developed and validated for the quantitative determination of nadolol in tablets. the HPLC method was performed on a C18 column with fluorescence detection. the excitation and emission wavelengths were 230 and 300nm, respectively. A mobile phase composed by acetonitrile-water containing 0.1% triethylamine (15:85v/v) and pH adjusted to 4.6 with formic acid was used. the UVDS method was performed taken a signal at 279.5nm. the correlation coefficient (r) obtained for both methods was 0.9999. the proposed methods are simple, precise, accurate, and can be used in routine analysis.
Citação
Analytical Letters. Philadelphia: Taylor & Francis Inc, v. 41, n. 3, p. 424-436, 2008.
Palavras-chave
nadolol tablets
HPLC
UV derivative spectrophotometry
URI
http://repositorio.unifesp.br/handle/11600/30307
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