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dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.authorNarikawa, Silvia
dc.contributor.authorMarques, Mariangela Esther Alencar
dc.identifier.citationPathology Research and Practice. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 204, n. 2, p. 97-104, 2008.
dc.description.abstractThe aim of this study was to investigate the expression of p53, caspase-3, bcl-2, MIB-1, and PCNA to validate more objective methods to differentiate squamous cell carcinoma and keratoacanthoma, as well as to understand their pathogenesis with accuracy. A total of 52 cases of histopathologically diagnosed keratoacanthoma in the proliferative stage and 56 cases of well-differentiated squamous cell carcinoma were selected in this study. the expression was evaluated by means of immunohistochemistry. Bcl-2 immunoreactivity was weak or absent in the majority of cases, either in squamous cell carcinoma or in keratoacanthoma. PCNA-positive cells did not show differences between two lesions evaluated. On the other hand, MIB-1 was statistically significant (p<0.05) between squamous cell carcinomas and keratoacanthomas. Moreover, p53 and caspase-3 were overexpressed in squamous cell carcinomas. Together, these results suggest that the biological behavior of the well-differentiated squanous cell carcinomas of the skin may be associated with cellular proliferation and/or deregulation of cell death, indicated by increased expression of the MIB-1 and apoptotic proteins p53 and caspase-3, respectively. (C) 2007 Elsevier GrnbH. All rights reserved.en
dc.publisherElsevier B.V.
dc.relation.ispartofPathology Research and Practice
dc.rightsAcesso restrito
dc.subjectSquamous cell carcinomaen
dc.subjectCell proliferationen
dc.titleExpression of apoptotic and cell proliferation regulatory proteins in keratoacanthomas and squamous cell carcinomas of the skinen
dc.contributor.institutionUniv Estadual Paulista
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv Estadual Paulista, São Paulo State Univ, Botucatu Med Sch, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUNIFESP, Universidade Federal de São Paulo, Dept Hlth Sci, Santos, SP, Brazil
dc.description.affiliationUnifespUNIFESP, Universidade Federal de São Paulo, Dept Hlth Sci, Santos, SP, Brazil
dc.description.sourceWeb of Science

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