• RI - Unifesp
    • Documentos
    • Tutoriais
    • Perguntas frequentes
    • Atendimento
    • Equipe
    • português (Brasil)
    • English
    • español
  • Sobre
    • RI Unifesp
    • Documentos
    • Tutoriais
    • Perguntas frequentes
    • Atendimento
    • Equipe
  • English 
    • português (Brasil)
    • English
    • español
    • português (Brasil)
    • English
    • español
  • Login
View Item 
  •   DSpace Home
  • Instituto de Saúde e Sociedade (ISS)
  • ISS - Artigos
  • View Item
  •   DSpace Home
  • Instituto de Saúde e Sociedade (ISS)
  • ISS - Artigos
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Expression of apoptotic and cell proliferation regulatory proteins in keratoacanthomas and squamous cell carcinomas of the skin

Thumbnail
Date
2008-01-01
Author
Ribeiro, Daniel Araki [UNIFESP]
Narikawa, Silvia
Marques, Mariangela Esther Alencar
Type
Artigo
ISSN
0344-0338
Is part of
Pathology Research and Practice
DOI
10.1016/j.prp.2007.10.005
Metadata
Show full item record
Abstract
The aim of this study was to investigate the expression of p53, caspase-3, bcl-2, MIB-1, and PCNA to validate more objective methods to differentiate squamous cell carcinoma and keratoacanthoma, as well as to understand their pathogenesis with accuracy. A total of 52 cases of histopathologically diagnosed keratoacanthoma in the proliferative stage and 56 cases of well-differentiated squamous cell carcinoma were selected in this study. the expression was evaluated by means of immunohistochemistry. Bcl-2 immunoreactivity was weak or absent in the majority of cases, either in squamous cell carcinoma or in keratoacanthoma. PCNA-positive cells did not show differences between two lesions evaluated. On the other hand, MIB-1 was statistically significant (p<0.05) between squamous cell carcinomas and keratoacanthomas. Moreover, p53 and caspase-3 were overexpressed in squamous cell carcinomas. Together, these results suggest that the biological behavior of the well-differentiated squanous cell carcinomas of the skin may be associated with cellular proliferation and/or deregulation of cell death, indicated by increased expression of the MIB-1 and apoptotic proteins p53 and caspase-3, respectively. (C) 2007 Elsevier GrnbH. All rights reserved.
Citation
Pathology Research and Practice. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 204, n. 2, p. 97-104, 2008.
Keywords
Keratoacanthoma
Squamous cell carcinoma
Cell proliferation
Apoptosis
URI
https://repositorio.unifesp.br/handle/11600/30295
Collections
  • ISS - Artigos [697]

DSpace software copyright © 2002-2016  DuraSpace
Contact Us
Theme by 
Atmire NV
 

 

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsBy Submit DateThis CollectionBy Issue DateAuthorsTitlesSubjectsBy Submit Date

My Account

Login

Statistics

View Usage Statistics

DSpace software copyright © 2002-2016  DuraSpace
Contact Us
Theme by 
Atmire NV