Expression of apoptotic and cell proliferation regulatory proteins in keratoacanthomas and squamous cell carcinomas of the skin

Expression of apoptotic and cell proliferation regulatory proteins in keratoacanthomas and squamous cell carcinomas of the skin

Author Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Narikawa, Silvia Google Scholar
Marques, Mariangela Esther Alencar Google Scholar
Institution Univ Estadual Paulista
Universidade Federal de São Paulo (UNIFESP)
Abstract The aim of this study was to investigate the expression of p53, caspase-3, bcl-2, MIB-1, and PCNA to validate more objective methods to differentiate squamous cell carcinoma and keratoacanthoma, as well as to understand their pathogenesis with accuracy. A total of 52 cases of histopathologically diagnosed keratoacanthoma in the proliferative stage and 56 cases of well-differentiated squamous cell carcinoma were selected in this study. the expression was evaluated by means of immunohistochemistry. Bcl-2 immunoreactivity was weak or absent in the majority of cases, either in squamous cell carcinoma or in keratoacanthoma. PCNA-positive cells did not show differences between two lesions evaluated. On the other hand, MIB-1 was statistically significant (p<0.05) between squamous cell carcinomas and keratoacanthomas. Moreover, p53 and caspase-3 were overexpressed in squamous cell carcinomas. Together, these results suggest that the biological behavior of the well-differentiated squanous cell carcinomas of the skin may be associated with cellular proliferation and/or deregulation of cell death, indicated by increased expression of the MIB-1 and apoptotic proteins p53 and caspase-3, respectively. (C) 2007 Elsevier GrnbH. All rights reserved.
Keywords Keratoacanthoma
Squamous cell carcinoma
Cell proliferation
Apoptosis
Language English
Date 2008-01-01
Published in Pathology Research and Practice. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 204, n. 2, p. 97-104, 2008.
ISSN 0344-0338 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 97-104
Origin https://dx.doi.org/10.1016/j.prp.2007.10.005
Access rights Closed access
Type Article
Web of Science ID WOS:000254172400003
URI https://repositorio.unifesp.br/handle/11600/30295

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