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dc.contributor.authorSmirnova, Anna S.
dc.contributor.authorFerreira-Silva, Katia C.
dc.contributor.authorMine, Karina L.
dc.contributor.authorAndrade-Oliveira, Vinicius
dc.contributor.authorShulzhenko, Natalia
dc.contributor.authorGerbase-DeLima, Maria
dc.contributor.authorMorgun, Andrey
dc.identifier.citationMolecular Immunology. Oxford: Pergamon-Elsevier B.V., v. 45, n. 1, p. 295-300, 2008.
dc.description.abstractLymphotoxin alpha (LTA) is a member of the TNF cytokine superfamily, produced principally by lymphocytes. It plays an important role in immune and inflammatory responses. Many TNF superfamily members have functionally important isoforms generated by alternative splicing but alternative splicing of LTA has never been studied. the known LTA protein is encoded by a transcript containing four exons. Here we report seven new LTA splice variants, three of them evolutionary conserved. We demonstrate their presence in cytoplasmic RNA suggesting that they could be translated into new LTA isoforms. We observed that their expression is differentially regulated upon activation of peripheral blood mononuclear cells and lymphocyte subpopulations (CD4+, CD8+, and CD19+). Our data suggest that the new LTA splice variants might play a role in the regulation of the immune response. (C) 2007 Elsevier B.V. All rights reserved.en
dc.publisherElsevier B.V.
dc.relation.ispartofMolecular Immunology
dc.rightsAcesso restrito
dc.subjectlymphotoxin alphaen
dc.subjectalternative splicingen
dc.subjectsplice variantsen
dc.subjectlymphocyte activationen
dc.subjectevolutionary conservationen
dc.titleDifferential expression of new LTA splice variants upon lymphocyte activationen
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv São Paulo, Inst Chem, Dept Biochem, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP EPM, Dept Pediat, Div Immunogenet, BR-04040031 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP EPM, Dept Pediat, Div Immunogenet, BR-04040031 São Paulo, Brazil
dc.description.sourceWeb of Science

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