Fundus autofluorescence of choroidal nevus and melanoma

Fundus autofluorescence of choroidal nevus and melanoma

Author Lavinsky, Daniel Autor UNIFESP Google Scholar
Belfort, Rubens Neto Autor UNIFESP Google Scholar
Navajas, Eduardo Autor UNIFESP Google Scholar
Torres, Virginia Autor UNIFESP Google Scholar
Martins, Maria Cristina Autor UNIFESP Google Scholar
Belfort, Rubens Junior Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: To describe autofluorescence patterns of choroidal melanocytic lesions using the Heidelberg Retinal Angiograph 2 system (HRA2).Methods: 20 patients with choroidal melanocytic lesions in the ocular fundus underwent ophthalmologic examination, fundus photography, autofluorescence and optical coherence tomography (OCT). Pathologic examination was performed on one enucleated eye with a large choroidal melanoma.Results: 15 patients had choroidal nevi and 5 had malignant choroidal melanoma ( 1 small, 1 medium and 3 large tumours). Choroidal nevi did not show any characteristic autofluorescence pattern, although secondary retinal pigment epithelium (RPE) changes, such as drusen and pigment epithelium detachment, appeared faintly hyperautofluorescent in 2 patients. Only the small malignant choroidal melanomas had prominent orange pigmentation, although all melanomas had an intense confluent hyperautofluorescent signal over the lesions. Pathology of one large malignant melanoma revealed lipofuscin underlying RPE.Conclusion: Most nevi did not have characteristic hyperautofluorescent features, but choroidal melanomas seemed to have a pattern of confluent hyperautofluorescence. Therefore, autofluorescence may be a useful non-invasive tool to assess lipofuscin in pigmented choroidal lesions, which may contribute to the diagnosis of malignancy. This hypothesis, however, remains to be confirmed in large prospective studies.
Language English
Date 2007-10-01
Published in British Journal of Ophthalmology. London: B M J Publishing Group, v. 91, n. 10, p. 1299-1302, 2007.
ISSN 0007-1161 (Sherpa/Romeo, impact factor)
Publisher B M J Publishing Group
Extent 1299-1302
Access rights Closed access
Type Article
Web of Science ID WOS:000249707900017

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