Polysaccaride pneumococcal antibodies - Placental transfer in normal infants and in patients with Down's syndrome and ataxia telangiectasia
Costa-Carvalho, Beatriz Tavares
Is part ofAllergy & Clinical Immunology International-Journal of the World Allergy Organization
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Background: Streptococcus pneumoniae is the most common cause of respiratory tract infections such as acute otitis media (AOM), sinusitis, and pneumonia in children. in addition, it is the leading cause of serious community-acquired infections including bacteremia and meningitis. the most effective strategy used to reduce the burden of disease caused by S. pneumoniae is vaccination. in the first months of life, maternal antibodies transferred by the placenta provide protection against some extracellular bacteria, but this protection can be reduced in infants born prematurely or of mothers with compromised immune defenses.Methods/Data base: A review of the literature, focusing on pneumococcal antibodies in cord blood and in two immunodeficiency groups: Ataxia telangiectasia (AT) and Down's syndrome (DS), also examining the effects of vaccination.Results/Conclusions: Infections by Streptococcus pneumoniae still remain a challenge to be solved, particularly in infants and in patients with immunologic disorders. Vaccination effects are reduced in Down syndrome and Ataxia-telangiectasia patients but perhaps the small quantity of antibodies produced can have some benefits for these patients.
CitationAllergy & Clinical Immunology International-Journal of the World Allergy Organization. Kirkland: Hogrefe & Huber Publishers, v. 19, n. 5, p. 201-205, 2007.
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